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FUT4 Polyclonal Antibody

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FUT4 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 19497-1-AP ( FUT4 Antibody) at dilution of 1:400 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

FUT4 Antibody in Western Blot (WB) — NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 19497-1-AP (FUT4 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

FUT4 Antibody in Immunoprecipitation (IP) — IP result of anti-FUT4 (IP:19497-1-AP, 4ug; Detection:19497-1-AP 1:500) with HeLa cells lysate 2480ug.

Product Details

19497-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:1,000	View 12 publications 12 publications
Immunohistochemistry (IHC)	-	View 4 publications 4 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:50-1:500	-
Immunocytochemistry (ICC/IF)	-	View 7 publications 7 publications
Immunoprecipitation (IP)	0.5-4.0 µg	-

Product Specifications
Species Reactivity	Human, Mouse
Published species	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Peptide
Conjugate	Unconjugated
Form	Liquid
Concentration	0.3 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

19497-1-AP antibody detects the native band around 59 kDa and glycosylated isoform proteins around 95-140 kDa in SDS-PAGE.

Target Information

FUT4 (Fucosyltransferase 4) is a Protein Coding gene. Diseases associated with FUT4 include Colon Adenocarcinoma and Liver Lymphoma. Among its related pathways are Glycosphingolipid biosynthesis - lacto and neolacto series and Mannose type O-glycan biosynthesis. Gene Ontology (GO) annotations related to this gene include fucosyltransferase activity and alpha-(1->3)-fucosyltransferase activity. The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Multivoxel magnetic resonance spectroscopy identifies enriched foci of cancer stem-like cells in high-grade gliomas.

OncoTargets and therapy

He T,Qiu T,Wang X,Gui H,Wang X,Hu Q,Xia H,Qi G,Wu J,Ma H

Thu Oct 01 00:00:00 EDT 2020

Multivoxel magnetic resonance spectroscopy identifies enriched foci of cancer stem-like cells in high-grade gliomas.

OncoTargets and therapy

He T,Qiu T,Wang X,Gui H,Wang X,Hu Q,Xia H,Qi G,Wu J,Ma H

Thu Oct 01 00:00:00 EDT 2020

Transcriptional Repression of p53 by PAX3 Contributes to Gliomagenesis and Differentiation of Glioma Stem Cells.

Frontiers in molecular neuroscience

Zhu H,Wang H,Huang Q,Liu Q,Guo Y,Lu J,Li X,Xue C,Han Q

Tue Sep 29 00:00:00 EDT 2020

FUT4 is involved in PD-1-related immunosuppression and leads to worse survival in patients with operable lung adenocarcinoma.

Journal of cancer research and clinical oncology

Liu C,Li Z,Wang S,Fan Y,Zhang S,Yang X,Hou K,Tong J,Hu X,Shi X,Wang X,Liu Y,Che X,Qu X

Tue Jan 01 00:00:00 EST 2019

AP1 mediates uPA/uPAR induced FUT4 expression and trophoblast invasion.

Journal of cellular biochemistry

Zheng Q,Yang Y,Cui X,Zhang D,Liu S,Yan Q

Wed Aug 01 00:00:00 EDT 2018

AP1 mediates uPA/uPAR induced FUT4 expression and trophoblast invasion.

Journal of cellular biochemistry

Zheng Q,Yang Y,Cui X,Zhang D,Liu S,Yan Q

Wed Aug 01 00:00:00 EDT 2018

Directing Induced Pluripotent Stem Cell Derived Neural Stem Cell Fate with a Three-Dimensional Biomimetic Hydrogel for Spinal Cord Injury Repair.

ACS applied materials & interfaces

Fan L,Liu C,Chen X,Zou Y,Zhou Z,Lin C,Tan G,Zhou L,Ning C,Wang Q

Wed May 30 00:00:00 EDT 2018

MicroRNA-200c impairs uterine receptivity formation by targeting FUT4 and α1,3-fucosylation.

Cell death and differentiation

Zheng Q,Zhang D,Yang YU,Cui X,Sun J,Liang C,Qin H,Yang X,Liu S,Yan Q

Fri Dec 01 00:00:00 EST 2017

MicroRNA-200c impairs uterine receptivity formation by targeting FUT4 and α1,3-fucosylation.

Cell death and differentiation

Zheng Q,Zhang D,Yang YU,Cui X,Sun J,Liang C,Qin H,Yang X,Liu S,Yan Q

Fri Dec 01 00:00:00 EST 2017

Novel function of pregnancy-associated plasma protein A: promotes endometrium receptivity by up-regulating N-fucosylation.

Scientific reports

Yu M,Wang J,Liu S,Wang X,Yan Q

Thu Jul 13 00:00:00 EDT 2017

Novel function of pregnancy-associated plasma protein A: promotes endometrium receptivity by up-regulating N-fucosylation.

Scientific reports

Yu M,Wang J,Liu S,Wang X,Yan Q

Thu Jul 13 00:00:00 EDT 2017

miR-200b inhibits proliferation and metastasis of breast cancer by targeting fucosyltransferase IV and α1,3-fucosylated glycans.

Oncogenesis

Zheng Q,Cui X,Zhang D,Yang Y,Yan X,Liu M,Niang B,Aziz F,Liu S,Yan Q,Liu J

Mon Jul 10 00:00:00 EDT 2017

miR-200b inhibits proliferation and metastasis of breast cancer by targeting fucosyltransferase IV and α1,3-fucosylated glycans.

Oncogenesis

Zheng Q,Cui X,Zhang D,Yang Y,Yan X,Liu M,Niang B,Aziz F,Liu S,Yan Q,Liu J

Mon Jul 10 00:00:00 EDT 2017

Fucosyltransferase-4 and Oligosaccharide Lewis Y Antigen as potentially Correlative Biomarkers of Helicobacter pylori CagA Associated Gastric Cancer.

Pathology oncology research : POR

Aziz F,Gao W,Yan Q

Sun Jan 01 00:00:00 EST 2017

Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions.

Toxicology in vitro : an international journal published in association with BIBRA

Aziz F,Wang X,Liu J,Yan Q

Tue Mar 01 00:00:00 EST 2016

Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions.

Toxicology in vitro : an international journal published in association with BIBRA

Aziz F,Wang X,Liu J,Yan Q

Tue Mar 01 00:00:00 EST 2016

Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4.

Oncotarget

Tian L,Shen D,Li X,Shan X,Wang X,Yan Q,Liu J

Tue Jan 12 00:00:00 EST 2016

Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4.

Oncotarget

Tian L,Shen D,Li X,Shan X,Wang X,Yan Q,Liu J

Tue Jan 12 00:00:00 EST 2016

Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death.

International journal of oncology

Shan X,Tian LL,Zhang YM,Wang XQ,Yan Q,Liu JW

Sat Aug 01 00:00:00 EDT 2015

Anti-LeY antibody enhances therapeutic efficacy of celecoxib against gastric cancer by downregulation of MAPKs/COX-2 signaling pathway: correlation with clinical study.

Journal of cancer research and clinical oncology

Aziz F,Yang X,Wang X,Yan Q

Wed Jul 01 00:00:00 EDT 2015

Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta-catenin signaling pathway.

FEBS letters

Zhang YM,Zhang YY,Bulbul A,Shan X,Wang XQ,Yan Q

Fri May 08 00:00:00 EDT 2015

Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta-catenin signaling pathway.

FEBS letters

Zhang YM,Zhang YY,Bulbul A,Shan X,Wang XQ,Yan Q

Fri May 08 00:00:00 EDT 2015

Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression.

International journal of oncology

Shan X,Aziz F,Tian LL,Wang XQ,Yan Q,Liu JW

Wed Apr 01 00:00:00 EDT 2015

Role of fucosyltransferase IV in epithelial-mesenchymal transition in breast cancer cells.

Cell death & disease

Yang X,Liu S,Yan Q

Thu Jul 25 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: 3-fucosyl-N-acetyl-lactosamine epitope; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase; alpha (1,3) fucosyltransferase, myeloid specific; alpha (1,3) fucosyltransferase, myeloid-specific; alpha 1,3-fucosyltransferase; Alpha-(1,3)-fucosyltransferase 4; ELAM ligand fucosyltransferase; ELAM-1 ligand fucosyltransferase; Fuc-TIV; Fucosyltransferase 4; fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific); Fucosyltransferase IV; fucT-IV; Galactoside 3-L-fucosyltransferase; Lewis X; stage-specific embryonic antigen 1

Gene Aliases: AI451562; CD15; ELFT; FAL; FCT3A; FUC-TIV; FucT-IV; FUT4; FUTIV; LeX; SSEA-1; Ssea1

UniProt ID: (Human) P22083, (Mouse) Q11127

Entrez Gene ID: (Human) 2526, (Mouse) 14345

Molecular Function: glycosyltransferase

Function(s)

carbohydrate metabolic process protein glycosylation protein N-linked glycosylation fucosylation L-fucose catabolic process

Process(es)

FUT4 Polyclonal Antibody

Product Details

19497-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Product Specific Information

Target Information

Bioinformatics

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