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Invitrogen
FXN Polyclonal Antibody
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Product Details
PA5-102473
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human FXN(Accession Q16595), corresponding to amino acid residues L140-L190.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total FXN.
Target Information
FXN is a mitochondrial protein which belongs to the FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA results in Friedreich ataxia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Frataxin, mitochondrial; Friedreich ataxia; Friedreich ataxia protein; Fxn
Gene Aliases: CyaY; FA; FARR; FRDA; FXN; RGD1565754; X25
UniProt ID: (Human) Q16595, (Mouse) O35943
Entrez Gene ID: (Human) 2395, (Rat) 499335, (Mouse) 14297
oxidative phosphorylation
heme biosynthetic process
ion transport
iron ion transport
cellular iron ion homeostasis
mitochondrion organization
adult walking behavior
aerobic respiration
embryo development ending in birth or egg hatching
response to iron ion
iron-sulfur cluster assembly
protein autoprocessing
proprioception
cellular cation homeostasis
mitochondrial respiratory chain complex III assembly
organ growth
regulation of growth
negative regulation of multicellular organism growth
negative regulation of apoptotic process
[2Fe-2S] cluster assembly
[4Fe-4S] cluster assembly
negative regulation of organ growth
muscle cell cellular homeostasis
positive regulation of lyase activity
protein maturation
cellular response to hydrogen peroxide
negative regulation of release of cytochrome c from mitochondria
inorganic ion homeostasis
positive regulation of cell proliferation
regulation of ferrochelatase activity
response to organic cyclic compound
iron incorporation into metallo-sulfur cluster
positive regulation of cell growth
response to drug
positive regulation of catalytic activity
positive regulation of axon extension
positive regulation of transferase activity
positive regulation of oxidoreductase activity
oxidation-reduction process
transport
iron ion homeostasis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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