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Invitrogen
Factor VII Monoclonal Antibody (RFF-VII/2)
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FIGURE: 1 / 1
Factor VII Antibody (MA5-16932) in IHC
Hepatic medicine : evidence and research 2025 -
Figure 6 Cytochrome P450 and coagulation factor in hepatocyte-like cells. The expression of cytochrome P450 enzymes and coagulation factors in marmoset ESC-derived HLCs was studied using antibodies against CYP1A2, CYP3A4, FVII and FIX. These cells were positive for each of the factors (stained in red), and cells were counterstained with DAPI (blue). ESCs and activin A-treated ESCs were negative controls, wh... View More
Product Details
MA5-16932
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
RFF-VII/2
Immunogen
Purified Factor VII
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody binds to a conformational epitope and will not bind to reduced Factor VII.
Mouse anti Human Factor VII antibody, clone RFF-VII/2 recognizes Factor VII, a serine protease found circulating in the blood. It initiates the extrinsic pathway of blood coagulation in conjunction with tissue factor.
Target Information
Coagulation factor VII is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in F7 production can cause coagulopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Coagulation factor VII; coagulation factor VII (serum prothrombin conversion accelerator); eptacog alfa; Factor 7; Factor7; FVII coagulation protein; Proconvertin; Serum prothrombin conversion accelerator; SPCA
Gene Aliases: F7; SPCA
UniProt ID: (Human) P08709
Entrez Gene ID: (Human) 2155
positive regulation of leukocyte chemotaxis
signal peptide processing
ER to Golgi vesicle-mediated transport
blood coagulation
blood coagulation, extrinsic pathway
circadian rhythm
positive regulation of platelet-derived growth factor receptor signaling pathway
response to organic cyclic compound
protein processing
peptidyl-glutamic acid carboxylation
positive regulation of blood coagulation
positive regulation of cell migration
organ regeneration
response to vitamin K
response to estrogen
positive regulation of positive chemotaxis
positive regulation of protein kinase B signaling
response to growth hormone
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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