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Invitrogen
Factor VIII Polyclonal Antibody
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FIGURE: 1 / 1
Factor VIII Antibody (PA5-106877) in WB
Western blot analysis of Factor VIII in various samples (Lane 1: mouse kidney lysate, Lane 2: mouse liver lysate, Lane 3: rat kidney lysate, Lane 4: rat kidney lysates treated with blocking peptide). Samples were incubated with Factor VIII polyclonal antibody (Product # PA5-106877).
Product Details
PA5-106877
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human F8(Accession P00451), corresponding to amino acid residues H2174-P2224.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Factor VIII.
Target Information
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AHF; Antihemophilic factor; Coagulation factor VIII; coagulation factor VIII A1 domain; coagulation factor VIII C2 domain; coagulation factor VIII, procoagulant component; coagulation factor VIIIc; Factor 8; Factor VIII; factor VIII F8B; factor8; Procoagulant component; RP11-115M6.7
Gene Aliases: AHF; Cf-8; Cf8; DXS1253E; F8; F8B; F8C; FVIII; HEMA
UniProt ID: (Mouse) Q06194, (Human) P00451
Entrez Gene ID: (Rat) 302470, (Mouse) 14069, (Human) 2157
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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