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Invitrogen

Fibronectin Polyclonal Antibody

View all (89) Fibronectin antibodies

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Product Details

PA5-88871

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein (or fragment)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3.5 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2805184

Product Specific Information

Positive Samples: U-87MG, NIH/3T3; Cellular Location: extracellular matrix, extracellular space

Target Information

Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230-250 kDa. In the extracellular matrix of several connective tissues and vessels, fibronectin is present as an insoluble protein that is extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. Fibronectin is most abundant during embryonic development and tissue remodeling. Fibronectin is also present at high concentrations as a soluble plasma protein. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins). Fibronectin is present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. Fibronectin has been implicated in carcinoma development in lung cancer. Further, Fibronectin expression is increased especially in non-small cell lung carcinoma. The adhesion of lung carcinoma cells to Fibronectin enhances tumorgenecity and confers resistance to apoptosis induced by standard chemotherapeutic agents. The gene encoding Fibronectin has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some Fibronectin variants has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CIG; Cold insoluble globulin (CIG); Cold-insoluble globulin; DKFZp686F10164; DKFZp686H0342; DKFZp686I1370; DKFZp686O13149; epididymis secretory sperm binding protein; extracellular matrix protein; ferritin L subunit; ferritin L-chain; Fibronectin; FN; lnc-ABCA12-8; Migration stimulating factor (MSF); migration-stimulating factor; unnamed protein product

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Gene Aliases: CIG; ED-B; FIBNEC; FINC; FN; fn-1; FN1; FNZ; GFND; GFND2; LETS; MSF; SMDCF

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UniProt ID: (Human) P02751

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Entrez Gene ID: (Human) 2335, (Rat) 25661

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Function(s)
protease binding receptor binding integrin binding extracellular matrix structural constituent protein binding collagen binding heparin binding peptidase activator activity identical protein binding proteoglycan binding receptor agonist activity mercury ion binding extracellular matrix structural protein
Process(es)
angiogenesis regulation of protein phosphorylation acute-phase response cell-substrate junction assembly cell adhesion cell-matrix adhesion calcium-independent cell-matrix adhesion integrin-mediated signaling pathway nervous system development heart development positive regulation of cell proliferation regulation of cell shape response to wounding positive regulation of gene expression response to muscle activity integrin activation substrate adhesion-dependent cell spreading endodermal cell differentiation wound healing endothelial cell migration positive regulation of axon extension positive regulation of fibroblast proliferation interaction with symbiont positive regulation of protein kinase B signaling regulation of ERK1 and ERK2 cascade negative regulation of transforming growth factor beta production blood coagulation, fibrin clot formation negative regulation of monocyte activation neural crest cell migration involved in autonomic nervous system development positive regulation of substrate-dependent cell migration, cell attachment to substrate ossification cell activation response to ischemia glial cell migration response to ozone positive regulation of peptidase activity peptide cross-linking extracellular matrix organization positive regulation of cell migration cellular response to vascular endothelial growth factor stimulus cellular response to platelet-derived growth factor stimulus negative regulation of apoptotic process positive regulation of chemotaxis response to glucocorticoid cellular response to lipopolysaccharide cellular response to mercury ion cellular response to glucose stimulus cellular response to interleukin-1 cellular response to prostaglandin E stimulus cellular response to transforming growth factor beta stimulus cellular response to BMP stimulus
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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