Invitrogen

Folliculin Polyclonal Antibody

View all (7) Folliculin antibodies

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Folliculin Antibody in Immunofluorescence (IF) — Immunofluorescent analysis of Folliculin using a polyclonal antibody (Product # PA5-23016).

Folliculin Antibody in Western Blot (WB) — Western blot analysis of Folliculin using a polyclonal antibody (Product # PA5-23016).

Product Details

Tested Applications

Dilution

Immunocytochemistry (ICC)

1:100

Immunofluorescence (IF)

1:100

Immunohistochemistry (Paraffin) (IHC (P))

5 µg/mL

Western Blot (WB)

1:1000

Product Specifications

Species Reactivity

Human, Mouse

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

N-terminal partial recombinant human FLCN protein expressed in E. coli.

Conjugate

Unconjugated

Form

Liquid

Storage buffer

whole serum

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_11157857

Product Specific Information

The target sequence has 95% sequence homology with canine, 92% sequence homology with rat and 91% sequence homology with bovine.

Target Information

FLCN is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in FLCN are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. Alternative splicing of FLCN results in two transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: BHD; BHD skin lesion fibrofolliculoma protein; Birt-Hogg-Dube syndrome protein; FLCL; Folliculin

Gene Aliases: AU014660; B430214A04Rik; BHD; FLCL; FLCN

UniProt ID: (Human) Q8NFG4, (Mouse) Q8QZS3

Entrez Gene ID: (Human) 201163, (Mouse) 216805

negative regulation of transcription from RNA polymerase II promoter in utero embryonic development regulation of protein phosphorylation positive regulation of protein phosphorylation cell-cell junction assembly positive regulation of autophagy negative regulation of gene expression negative regulation of mitochondrion organization hemopoiesis negative regulation of cell growth negative regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway TOR signaling regulation of TOR signaling negative regulation of TOR signaling positive regulation of TOR signaling regulation of cytokinesis negative regulation of Rho protein signal transduction regulation of histone acetylation positive regulation of apoptotic process positive regulation of GTPase activity positive regulation of cell adhesion positive regulation of transcription from RNA polymerase II promoter negative regulation of protein kinase B signaling negative regulation of ERK1 and ERK2 cascade negative regulation of protein localization to nucleus negative regulation of cell proliferation involved in kidney development negative regulation of energy homeostasis regulation of pro-B cell differentiation negative regulation of ATP biosynthetic process negative regulation of angiogenesis negative regulation of transcription, DNA-templated negative regulation of cellular respiration negative regulation of mitochondrial DNA metabolic process negative regulation of muscle tissue development negative regulation of post-translational protein modification positive regulation of intrinsic apoptotic signaling pathway

Process(es)

guanyl-nucleotide exchange factor activity protein binding protein complex binding