Invitrogen

Folliculin Polyclonal Antibody

View all (11) Folliculin antibodies

Questions & Answers

Questions & Answers

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Folliculin Antibody in Immunocytochemistry (ICC/IF) — Immunocytochemistry analysis of Folliculin in HeLa cells. Samples were incubated in Folliculin polyclonal antibody (Product # PA5-23016). Nuclei (Blue) are counterstained using Hoechst 33258.

Folliculin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of Folliculin in formalin-fixed paraffin-embedded tissue section of human pulmonary squamous cell carcinoma. Samples were incubated in Folliculin polyclonal antibody (Product # PA5-23016) using a dilution of 5 µg/mL. Cytoplasmic-nuclear immunostaining of Folliculin protein was observed in the various cells and interestingly, the staining was intense and localized more towards the cell membranes in a bunch of cells having mesenchymal morphology. [Magnification 40X].

Folliculin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of Folliculin in formalin-fixed paraffin-embedded tissue section of human esophageal squamous cell carcinoma (SCC). Samples were incubated in Folliculin polyclonal antibody (Product # PA5-23016) using a dilution of 5 µg/mL. The SCC cells as well as the associated stromal cells depicted strong cytoplasmic-nuclear immunostaining of Folliculin protein. The staining was more intense in the carcinoma cells compared to the tumor stroma [Magnification 10X].

Folliculin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of Folliculin in formalin-fixed paraffin-embedded tissue section of human bladder cancer. Samples were incubated in Folliculin polyclonal antibody (Product # PA5-23016) using a dilution of 5 µg/mL. The carcinoma cells as well as the various stromal cells depicted cytoplasmic- nuclear immunostaining for Folliculin protein. The cytoplasmic staining was more intense in the carcinoma cells compared to tumor stroma [Magnification 40X].

Folliculin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of Folliculin in formalin-fixed paraffin-embedded tissue section of normal skin from human. Samples were incubated in Folliculin polyclonal antibody (Product # PA5-23016) using a dilution of 5 µg/mL. Intense cytoplasmic with moderate nuclear immunostaining of Folliculin protein was observed in the various cells of the epidermal layer [Magnification 40X].

Folliculin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of Folliculin in formalin-fixed paraffin-embedded tissue section of normal liver of human. Samples were incubated in Folliculin polyclonal antibody (Product # PA5-23016) using a dilution of 5 µg/mL. Strong cytoplasmic-nuclear immunopositivity of Folliculin protein was observed in hepatocytes [Magnification 10X].

Folliculin Antibody in Western Blot (WB) — Western blot analysis of Folliculin in HeLa whole cell lysate. Samples were incubated in Folliculin polyclonal antibody (Product # PA5-23016). FLCN isoforms 1, 2 and 3..

Product Details

PA5-23016

Applications	Tested Dilution	Publications
Western Blot (WB)	1:1,000	-
Immunohistochemistry (Paraffin) (IHC (P))	1:50-1:200	-
Immunocytochemistry (ICC/IF)	1:100	-

Product Specifications
Species Reactivity	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	N-terminal partial recombinant human FLCN protein expressed in E. coli. View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	Conc. Not Determined
Storage buffer	whole serum
Contains	0.1% sodium azide
Storage conditions	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID	AB_11157857

Product Specific Information

The target sequence has 95% sequence homology with canine, 92% sequence homology with rat and 91% sequence homology with bovine.

Target Information

This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. A chicken homolog of this protein promotes mitochondrial fission and the mouse homolog protects cells from oxidative stress. A related pseudogene of this gene is found on chromosome X.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BHD skin lesion fibrofolliculoma protein; Birt-Hogg-Dube syndrome protein; Birt-Hogg-Dube syndrome protein homolog; Folliculin

Gene Aliases: AU014660; B430214A04Rik; BHD; FLCL; FLCN

UniProt ID: (Human) Q8NFG4, (Mouse) Q8QZS3

Entrez Gene ID: (Human) 201163, (Mouse) 216805

negative regulation of transcription from RNA polymerase II promoter in utero embryonic development regulation of protein phosphorylation positive regulation of protein phosphorylation cell-cell junction assembly positive regulation of autophagy negative regulation of gene expression negative regulation of mitochondrion organization hemopoiesis negative regulation of cell growth negative regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway TOR signaling regulation of TOR signaling negative regulation of TOR signaling positive regulation of TOR signaling regulation of cytokinesis negative regulation of Rho protein signal transduction regulation of histone acetylation positive regulation of apoptotic process positive regulation of GTPase activity positive regulation of cell adhesion positive regulation of transcription from RNA polymerase II promoter negative regulation of protein kinase B signaling negative regulation of ERK1 and ERK2 cascade negative regulation of protein localization to nucleus negative regulation of cell proliferation involved in kidney development negative regulation of energy homeostasis regulation of pro-B cell differentiation negative regulation of ATP biosynthetic process negative regulation of angiogenesis negative regulation of transcription, DNA-templated negative regulation of cellular respiration negative regulation of mitochondrial DNA metabolic process negative regulation of muscle tissue development negative regulation of post-translational protein modification positive regulation of intrinsic apoptotic signaling pathway

Process(es)

guanyl-nucleotide exchange factor activity protein binding protein complex binding