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G6PC Polyclonal Antibody

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Antibody Testing Data (3)

G6PC Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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G6PC Antibody (22169-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver tissue slide using (Product # 22169-1-AP) (G6PC antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

22169-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

View 27 publications 27 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

G6PC Fusion Protein Ag17839 (1-60 aa encoded by BC130478)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEEGMNVLH DFGIQSTHYL QVNYQDSQDW FILVSVIADL RNAFYVLFPI WFHLQEAVGI K (1-60 aa encoded by BC130478)

Target Information

Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects in the enzyme cause glycogen storage disease type I.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Aspirin Suppresses Hepatic Glucagon Signaling Through Decreasing Production of Thromboxane A2.

Endocrinology

Dai Y,Xu R,Wu G,Yin Z,Zhang H,Li H,Chen W

Mon Jan 09 00:00:00 EST 2023

The 15-hydroxyprostaglandin dehydrogenase inhibitor SW033291 ameliorates abnormal hepatic glucose metabolism through PGE₂-EP4 receptor-AKT signaling in a type 2 diabetes mellitus mouse model.

Cellular signalling

Liang M,Wang L,Wang W

Tue Aug 01 00:00:00 EDT 2023

Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice.

American journal of physiology. Endocrinology and metabolism

Rome FI,Shobert GL,Voigt WC,Stagg DB,Puchalska P,Burgess SC,Crawford PA,Hughey CC

Sun Jan 01 00:00:00 EST 2023

Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting.

Molecular cell

Zhao Y,Li S,Chen Y,Wang Y,Wei Y,Zhou T,Zhang Y,Yang Y,Chen L,Liu Y,Hu C,Zhou B,Ding Q

Thu Apr 06 00:00:00 EDT 2023

G-protein coupled receptor 19 (GPR19) knockout mice display sex-dependent metabolic dysfunction.

Scientific reports

Mushala BAS,Xie B,Sipula IJ,Stoner MW,Thapa D,Manning JR,Bugga P,Vandevender AM,Jurczak MJ,Scott I

Sat Apr 15 00:00:00 EDT 2023

Douchi Peptides VY and SFLLR Improve Glucose Homeostasis and Gut Dysbacteriosis in High-Fat Diet-Induced Insulin Resistant Mice.

Molecular nutrition & food research

Yu S,Wang W,Wang H,Bu T,Liu L,Zhao R,Li S,Liu D,Wu J

Mon May 01 00:00:00 EDT 2023

Transcriptional coactivation by EHMT2 restricts glucocorticoid-induced insulin resistance in a study with male mice.

Nature communications

Lee RA,Chang M,Yiv N,Tsay A,Tian S,Li D,Poulard C,Stallcup MR,Pufall MA,Wang JC

Tue May 30 00:00:00 EDT 2023

Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice.

Journal of genetics and genomics = Yi chuan xue bao

Wu J,Chen Y,Li X,Ran L,Liu X,Wang X,Zhen M,Shao S,Zeng L,Wang C,Liang B,Zhao J,Wu Y

Fri Apr 01 00:00:00 EDT 2022

20(S)-ginsenoside Rh1 alleviates T2DM induced liver injury via the Akt/FOXO1 pathway.

Chinese journal of natural medicines

Su WY,Fan ML,Li Y,Hu JN,Cai EB,Zhu HY,Song MJ,Li W

Thu Sep 01 00:00:00 EDT 2022

Paternal High-Fat Diet Altered Sperm 5'tsRNA-Gly-GCC Is Associated With Enhanced Gluconeogenesis in the Offspring.

Frontiers in molecular biosciences

Wang B,Xia L,Zhu D,Zeng H,Wei B,Lu L,Li W,Shi Y,Liu J,Zhang Y,Sun M

Sat Jul 16 00:00:00 EDT 2022

NFYA promotes the anti-tumor effects of gluconeogenesis in hepatocellular carcinoma through the regulation of PCK1 expression.

Frontiers in cell and developmental biology

Tsujimoto G,Ito R,Yoshikawa K,Ueki C,Okada N

Tue Sep 13 00:00:00 EDT 2022

Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction.

Molecular metabolism

Rome FI,Hughey CC

Fri Apr 01 00:00:00 EDT 2022

Comparative analysis of long non‑coding RNA expression profiles induced by resveratrol and metformin treatment for hepatic insulin resistance.

International journal of molecular medicine

Shu L,Hou X,Song G,Wang C,Ma H

Mon Nov 01 00:00:00 EDT 2021

Exercise ameliorates insulin resistance and improves SIRT6-mediated insulin signaling transduction in liver of obese rats.

Canadian journal of physiology and pharmacology

Zhang Y,Yang Z,Xu Z,Wan J,Hua T,Sun Q

Sat May 01 00:00:00 EDT 2021

Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression.

Human cell

Cheng L,Yu P,Li F,Jiang X,Jiao X,Shen Y,Lai X

Mon Nov 01 00:00:00 EDT 2021

Long non-coding RNA expression profiling following treatment with resveratrol to improve insulin resistance.

Molecular medicine reports

Shu L,Hou G,Zhao H,Huang W,Song G,Ma H

Sat Aug 01 00:00:00 EDT 2020

Resveratrol Upregulates mmu-miR-363-3p via the PI3K-Akt Pathway to Improve Insulin Resistance Induced by a High-Fat Diet in Mice.

Diabetes, metabolic syndrome and obesity : targets and therapy

Shu L,Zhao H,Huang W,Hou G,Song G,Ma H

Wed Apr 13 00:00:00 EDT 2022

The NQO1/PKLR axis promotes lymph node metastasis and breast cancer progression by modulating glycolytic reprogramming.

Cancer letters

Yang Y,Zhu G,Dong B,Piao J,Chen L,Lin Z

Mon Jul 01 00:00:00 EDT 2019

The NQO1/PKLR axis promotes lymph node metastasis and breast cancer progression by modulating glycolytic reprogramming.

Cancer letters

Yang Y,Zhu G,Dong B,Piao J,Chen L,Lin Z

Mon Jul 01 00:00:00 EDT 2019

Adropin reduces blood glucose levels in mice by limiting hepatic glucose production.

Physiological reports

Thapa D,Xie B,Manning JR,Zhang M,Stoner MW,Huckestein BR,Edmunds LR,Zhang X,Dedousis NL,O'Doherty RM,Jurczak MJ,Scott I

Mon Apr 01 00:00:00 EDT 2019

Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.

Toxicology

Wang F,Chang C,Li R,Zhang Z,Jiang H,Zeng N,Li D,Chen L,Xiao Y,Chen W,Wang Q

Thu Aug 01 00:00:00 EDT 2019

Resveratrol affects hepatic gluconeogenesis via histone deacetylase 4.

Diabetes, metabolic syndrome and obesity : targets and therapy

Zhao H,Shu L,Huang W,Song G,Ma H

Fri Apr 08 00:00:00 EDT 2022

Micro-RNA-27a/b negatively regulates hepatic gluconeogenesis by targeting FOXO1.

American journal of physiology. Endocrinology and metabolism

Wang S,Ai H,Liu L,Zhang X,Gao F,Zheng L,Yi J,Sun L,Yu C,Zhao H,Li Y

Fri Nov 01 00:00:00 EDT 2019

Vaccarin ameliorates insulin resistance and steatosis by activating the AMPK signaling pathway.

European journal of pharmacology

Lei Y,Gong L,Tan F,Liu Y,Li S,Shen H,Zhu M,Cai W,Xu F,Hou B,Zhou Y,Han H,Qiu L,Sun H

Wed May 15 00:00:00 EDT 2019

Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.

Pharmacological research

Yan J,Wang C,Jin Y,Meng Q,Liu Q,Liu Z,Liu K,Sun H

Sun Apr 01 00:00:00 EDT 2018

Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.

Pharmacological research

Yan J,Wang C,Jin Y,Meng Q,Liu Q,Liu Z,Liu K,Sun H

Sun Apr 01 00:00:00 EDT 2018

Effects of calycosin against high-fat diet-induced nonalcoholic fatty liver disease in mice.

Journal of gastroenterology and hepatology

Duan X,Meng Q,Wang C,Liu Z,Sun H,Huo X,Sun P,Ma X,Peng J,Liu K

Thu Feb 01 00:00:00 EST 2018

Effects of calycosin against high-fat diet-induced nonalcoholic fatty liver disease in mice.

Journal of gastroenterology and hepatology

Duan X,Meng Q,Wang C,Liu Z,Sun H,Huo X,Sun P,Ma X,Peng J,Liu K

Thu Feb 01 00:00:00 EST 2018

1,2-Dichloroethane impairs glucose and lipid homeostasis in the livers of NIH Swiss mice.

Toxicology

Wang T,Xu D,Fan Q,Rong W,Zheng J,Gao C,Li G,Zeng N,Guo T,Zeng L,Wang F,Xiao C,Cai L,Tang S,Deng X,Yin X,Huang M,Lu F,Hu Q,Chen W,Huang Z,Wang Q

Sat Apr 01 00:00:00 EDT 2017

1,2-Dichloroethane impairs glucose and lipid homeostasis in the livers of NIH Swiss mice.

Toxicology

Wang T,Xu D,Fan Q,Rong W,Zheng J,Gao C,Li G,Zeng N,Guo T,Zeng L,Wang F,Xiao C,Cai L,Tang S,Deng X,Yin X,Huang M,Lu F,Hu Q,Chen W,Huang Z,Wang Q

Sat Apr 01 00:00:00 EDT 2017

Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis.

The Journal of biological chemistry

Jiang L,Xiong J,Zhan J,Yuan F,Tang M,Zhang C,Cao Z,Chen Y,Lu X,Li Y,Wang H,Wang L,Wang J,Zhu WG,Wang H

Fri Aug 11 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: G-6-Pase; G6Pase-alpha; Glc-6-Pase-alpha; Glucose-6-phosphatase; Glucose-6-phosphatase alpha; Glucose-6-phosphatase catalytic subunit 1; glucose-6-phosphatase, catalytic subunit; MGC163350

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Gene Aliases: AW107337; G6Pase; G6PC; G6PC1; G6PT; Glc-6-Pase; GSD1; GSD1a

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UniProt ID: (Human) P35575, (Mouse) P35576

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Entrez Gene ID: (Human) 2538, (Mouse) 14377

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Function(s)

glucose-6-phosphatase activity phosphotransferase activity, alcohol group as acceptor phosphate ion binding catalytic activity hydrolase activity phosphatase

Process(es)

glycogen metabolic process glycogen catabolic process gluconeogenesis triglyceride metabolic process steroid metabolic process regulation of gene expression glucose transport glucose-6-phosphate transport response to food multicellular organism growth glucose homeostasis cholesterol homeostasis urate metabolic process phosphorylated carbohydrate dephosphorylation glucose 6-phosphate metabolic process phosphate-containing compound metabolic process dephosphorylation lipid homeostasis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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G6PC Polyclonal Antibody

G6PC Antibody (22169-1-AP) in IHC (P)

Product Details

22169-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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