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GABA-A-R-Gamma2L and GABA-A-R-Gamma2S are two splice variants of the gamma2 subunit of the GABA-A receptor, which is crucial for mediating inhibitory neurotransmission in the central nervous system. The gamma2L (long) variant includes an extra eight amino acids compared to the gamma2S (short) variant, potentially influencing the receptor's synaptic localization and pharmacological properties. Both variants are essential for the receptor's proper function, and their dysregulation can be associated with neurological disorders such as epilepsy and anxiety.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GABA(A) receptor subunit gamma-2; GABA(A) receptor, gamma 2; GABAAR subunit gamma-2; gamma-aminobutyric acid A receptor, gamma 2; gamma-aminobutyric acid (GABA) A receptor, gamma 2; gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2; gamma-aminobutyric acid A receptor, gamma 2; Gamma-aminobutyric acid receptor subunit gamma-2
Gene Aliases: CAE2; ECA2; GABAA-R; Gabrg-2; GABRG2; gamma2; GEFSP3
UniProt ID: (Human) F5HB82, (Mouse) P22723, (Rat) P18508
Entrez Gene ID: (Human) 2566, (Mouse) 14406, (Rat) 29709
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