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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 268 and 532 of Human GABA B Receptor 1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-27725 targets GABA B Receptor 1 in WB applications and shows reactivity with Human and mouse samples.
The PA5-27725 immunogen is recombinant fragment corresponding to a region within amino acids 268 and 532 of Human GABA B Receptor 1.
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a); dJ271M21.1.1; dJ271M21.1.2; GABA-B receptor 1; GABA-B receptor, R1 subunit; GABA-B-R1; GABA-BR1; GABA-BR1b receptor; GABAB; GABABR1; GABBR1-3; gamma-aminobutyric acid (GABA) B receptor, 1; gamma-aminobutyric acid (GABA-B) receptor, 1; Gamma-aminobutyric acid type B receptor subunit 1; GB1; GPRC3A; seven transmembrane helix receptor; subunit 1c
bM573K1.1; GABAB1; GABABR1; GABBR1; GABBR1-3; GB1; GPRC3A