Immunogen sequence: AVEELLVAAQ RQDRLTVGVY ESAKLMNVDP DSVVLCLLAI DEEEEDDIAL QIHFTLIQSF CCDNDINIVR VSGMQRLAQL LGEPAETQGT TEARDLHCLL VTNPHTDAWK SHGLVEVASY CEESRGNNQW VPY
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 94%.
Cellcycle progression issubject to arrest at G1 and G2 checkpointsin response to DNA damage, presumablyto allow time for DNA repair prior to entryinto S andMphase, respectively. The p53 tumorsuppressor isrequired for one such G1 checkpoint and functionsto upregulate expression of GADD 45 and p21. GADD 45 binds both Cdks and PCNA, a protein involved in DNA replication and repair. GADD 45 stimulates DNA excision repair in vitro and inhibits entry ofcellsinto S phase. Thus, it has been suggested that GADD 45 mayserve as a link between the p53-dependentcellcycle checkpoint and DNA repair. GADD 45-like proteins, GADD 45 beta and GADD 45 gamma, have been shown to be induced by environmentalstresses. GADD 45 beta and GADD 45 gamma are thought to induce p38/JNK activation via MEKK4 activation.
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Protein Aliases: GADD45B; Growth arrest and DNA damage-inducible protein GADD45 beta; growth arrest and DNA-damage-inducible, beta; MYD118; Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118
Gene Aliases: GADD45B; GADD45BETA; MYD118
UniProt ID: (Human) O75293
Entrez Gene ID: (Human) 4616