Product References
DYRK1A inhibitors leucettines and TGF-β inhibitor additively stimulate insulin production in beta cells, organoids, and isolated mouse islets.
PloS one
Pucelik B,Barzowska A,Czarna A
PA1-16777 was used in Western Blotting to show that leucettines, known to be DYRK1A kinase inhibitors, can improve glucose-stimulated insulin secretion (GSIS) in rodent β-cells and isolated islets, as well as in hiPSC-derived β-cells islets.
Fri May 19 00:00:00 EDT 2023
Absence of Scaffold Protein Tks4 Disrupts Several Signaling Pathways in Colon Cancer Cells.
International journal of molecular sciences
Jacksi M,Schad E,Buday L,Tantos A
PA1-16777 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to show a significant perturbation of gene expression upon the deletion of Tks4, suggesting the involvement of different signal transduction pathways over the well-known EGFR signaling.
Mon Jan 09 00:00:00 EST 2023
GDP polyribonucleotidyltransferase domain of vesicular stomatitis virus polymerase regulates leader-promoter escape and polyadenylation-coupled termination during stop-start transcription.
PLoS pathogens
Ogino M,Green TJ,Ogino T
PA1-16777 was used in Western Blot to study the functions of basic amino acid residues close to the vesicular stomatitis virus GDP polyribonucleotidyltransferase (PRNTase) active site in RNA biosynthesis, and identify two amino acid residues that regulate stop-start transcription at previously unappreciated steps.
Tue Feb 01 00:00:00 EST 2022
Detection of exogenous DNA uptake by murine dendritic cells.
STAR protocols
Celias DP,de Mingo Pulido Á,Ruffell B
PA1-16777 was used in Immunocytochemistry to measure exogenous DNA uptake by murine dendritic cells (DCs) using supernatant containing cellular debris, which allows for DNA uptake in the absence of transfection reagents.
Fri Sep 16 00:00:00 EDT 2022
Detection of exogenous DNA uptake by murine dendritic cells.
STAR protocols
Celias DP,de Mingo Pulido Á,Ruffell B
PA1-16777 was used in Immunocytochemistry to measure exogenous DNA uptake by murine dendritic cells (DCs) using supernatant containing cellular debris, which allows for DNA uptake in the absence of transfection reagents.
Fri Sep 16 00:00:00 EDT 2022
TRPM2 regulates autophagy to participate in hepatitis B virus replication.
Journal of viral hepatitis
Chen L,Zhu L,Lu X,Ming X,Yang B
PA1-16777 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to indicate that Hepatitis B virus (HVB) infection promotes TRPM2 expression, and TRPM2 interacts with p47 phox to induce autophagy and facilitate HVB replication.
Mon Aug 01 00:00:00 EDT 2022
MiR-30b-5p attenuates the inflammatory response and facilitates the functional recovery of spinal cord injury by targeting the NEFL/mTOR pathway.
Brain and behavior
Zhang H,Wang D,Tong J,Fang J,Lin Z
PA1-16777 was used in Western Blotting to investigate the role of Neurofilament Light Chain (NEFL) and its interaction with miR-30b-5p in spinal cord injury (SCI).
Thu Dec 01 00:00:00 EST 2022
Downregulation of circATXN7 represses non-small cell lung cancer growth by releasing miR-7-5p.
Thoracic cancer
Li D,Fu Z,Dong C,Song Y
PA1-16777 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to conclude that CircATXN7 accelerated the malignancy of NSCLC cells through adsorbing miR-7-5p and upregulating PFN2, offering evidence to support circATXN7 as a target for NSCLC treatment.
Wed Jun 01 00:00:00 EDT 2022
The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake.
Immunity
de Mingo Pulido Á,Hänggi K,Celias DP,Gardner A,Li J,Batista-Bittencourt B,Mohamed E,Trillo-Tinoco J,Osunmakinde O,Peña R,Onimus A,Kaisho T,Kaufmann J,McEachern K,Soliman H,Luca VC,Rodriguez PC,Yu X,Ruffell B
PA1-16777 was used in Immunocytochemistry to report that increased CXCL9 expression by splenic cDC1s upon TIM-3 blockade required type I interferons and extracellular DNA.
Tue Jun 08 00:00:00 EDT 2021
Aberrant expression of semaphorin 6B affects cell phenotypes in thyroid carcinoma by activating the Notch signalling pathway.
Endokrynologia Polska
Lv XJ,Chen X,Wang Y,Yu S,Pang L,Huang C
PA1-16777 was used in Western Blot to demonstrate that SEMA6B exerts a tumourigenic effect in thyroid carcinoma partly by activating Notch signalling pathway, which provides a possible biomarker for the therapeutic intervention in thyroid carcinoma.
Wed Oct 20 00:00:00 EDT 2021
Activation of Cx43 Hemichannels Induces the Generation of Ca2+ Oscillations in White Adipocytes and Stimulates Lipolysis.
International journal of molecular sciences
Turovsky EA,Varlamova EG,Turovskaya MV
PA1-16777 was used in Western Blotting to investigate the mechanisms of Ca2+ oscillation generation upon activation of connexin-43 and regulation of the lipolysis/lipogenesis balance in white adipocytes through vesicular ATP release.
Wed Jul 28 00:00:00 EDT 2021
Novel compound mutations in the mitochondrial translation elongation factor (TSFM) gene cause severe cardiomyopathy with myocardial fibro-adipose replacement.
Scientific reports
Perli E,Pisano A,Glasgow RIC,Carbo M,Hardy SA,Falkous G,He L,Cerbelli B,Pignataro MG,Zacara E,Re F,Della Monica PL,Morea V,Bonnen PE,Taylor RW,d'Amati G,Giordano C
PA1-16777 was used in Western Blotting to report an unusual presentation of mitochondrial cardiomyopathy, with dilated phenotype and pathologic evidence of biventricular fibro-adipose replacement, in a 33-year old woman who underwent cardiac transplant.
Mon Mar 25 00:00:00 EDT 2019
Increased MIR31HG lncRNA expression increases gefitinib resistance in non-small cell lung cancer cell lines through the EGFR/PI3K/AKT signaling pathway.
Oncology letters
Wang B,Jiang H,Wang L,Chen X,Wu K,Zhang S,Ma S,Xia B
Published figure using GAPDH polyclonal antibody (Product # PA1-16777) in Western Blot
Mon May 01 00:00:00 EDT 2017
PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells.
Acta physiologica (Oxford, England)
Josipovic I,Fork C,Preussner J,Prior KK,Iloska D,Vasconez AE,Labocha S,Angioni C,Thomas D,Ferreirós N,Looso M,Pullamsetti SS,Geisslinger G,Steinhilber D,Brandes RP,Leisegang MS
PA1-16777 was used in western blot to analyze maintenance of an angiogenic phenotype in human endothelial cells by PAFAH1B1 and the IncRNA NONHSAT073641
Thu Sep 01 00:00:00 EDT 2016
Characterization of metastatic tumor antigen 1 and its interaction with hepatitis B virus X protein in NF-κB signaling and tumor progression in a woodchuck hepatocellular carcinoma model.
Oncotarget
Li YT,Liu CJ,Su TH,Cheng HR,Jeng YM,Lin HL,Wang CC,Kao JH,Chen PJ,Chen DS,Wu HL
PA116777 was used in western blot to explore the role of metastatic tumor antigen 1 in hepatitis B-associated hepatocarcinogenesis in the woodchuck model
Tue Jul 26 00:00:00 EDT 2016