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GATA-4 Polyclonal Antibody

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GATA-4 Polyclonal Antibody

Product Details

39893

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

This GATA-4 antibody was raised against a peptide derived from the C-terminus of human GATA-4.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.66 mg/mL

Amount

66 µg

Purification

Antigen affinity chromatography

Storage buffer

70mM tris, pH 8, with 105mM NaCl, 0.07mM EDTA, 31mM glycine, 30% glycerol

Contains

0.035% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2615046

Target Information

GATA4 is a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in the gene encoding GATA4 have been associated with cardiac septal defects.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: GAT4; GATA-binding factor 4; GATA-binding protein 4; MGC126629; putative; Transcription factor GATA-4; unnamed protein product

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Gene Aliases: ASD2; Gata-4; GATA4; TACHD; TOF; VSD1

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UniProt ID: (Human) P43694, (Mouse) Q08369

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Entrez Gene ID: (Human) 2626, (Mouse) 14463

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding protein kinase binding sequence-specific DNA binding metal ion binding NFAT protein binding RNA polymerase II sequence-specific DNA binding transcription factor binding co-SMAD binding DNA-binding transcription factor binding sequence-specific double-stranded DNA binding transcription factor activity, RNA polymerase II transcription factor binding enhancer sequence-specific DNA binding chromatin binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription coactivator activity transcription factor binding activating transcription factor binding transcription regulatory region DNA binding DNA-binding transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter heart looping atrioventricular node development aortic valve morphogenesis atrioventricular valve formation endocardial cushion development cardiac ventricle morphogenesis cardiac right ventricle morphogenesis ventricular septum development atrial septum primum morphogenesis atrial septum secundum morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell-cell signaling endoderm development heart development male gonad development response to xenobiotic stimulus response to mechanical stimulus anatomical structure morphogenesis tissue development negative regulation of autophagy positive regulation of vascular endothelial growth factor production negative regulation of cardiac muscle cell apoptotic process cell differentiation positive regulation of BMP signaling pathway response to vitamin A embryonic heart tube anterior/posterior pattern specification atrioventricular canal development wound healing cell fate commitment positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic foregut morphogenesis cardiac muscle cell differentiation transdifferentiation atrial septum morphogenesis intestinal epithelial cell differentiation cardiac muscle tissue regeneration cell growth involved in cardiac muscle cell development cellular response to glucose stimulus regulation of cardiac muscle cell contraction negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway in utero embryonic development gastrulation with mouth forming second endoderm formation heart morphogenesis outflow tract morphogenesis atrioventricular valve morphogenesis mitral valve formation tricuspid valve formation ventricular cardiac muscle tissue development cardiac septum development transcription, DNA-templated transcription from RNA polymerase II promoter spermatogenesis regulation of gene expression cardiac muscle hypertrophy in response to stress signal transduction involved in regulation of gene expression BMP signaling pathway response to retinoic acid embryonic heart tube development tube morphogenesis skeletal muscle cell differentiation response to drug response to estrogen embryonic digestive tract morphogenesis embryonic morphogenesis cardiac muscle tissue development Sertoli cell differentiation regulation of cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation canonical Wnt signaling pathway SMAD protein signal transduction lung morphogenesis lung lobe formation diaphragm morphogenesis vasculogenesis involved in coronary vascular morphogenesis cellular response to gonadotropin stimulus cellular response to follicle-stimulating hormone stimulus epithelial cell fate commitment seminiferous tubule development
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