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Invitrogen
GATA6 Polyclonal Antibody
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Product Details
PA5-40438
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human GATA6
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: SGAGAPVMTG AGESTNPENS ELKYSGQDGL YIGVSLASPA EVTSSVRPDS
Sequence homology: Cow: 86%; Guinea Pig: 85%; Horse: 100%; Human: 100%; Mouse: 79%; Pig: 93%; Rabbit: 93%; Rat: 86%; Sheep: 93%
Target Information
The GATA6 gene encodes a member of the GATA family of zinc-finger transcription factors, which are critical in regulating gene expression during development. GATA6 plays a crucial role in the differentiation and development of multiple tissues, including the heart and gastrointestinal tract, by interacting with other transcriptional regulators through its zinc-finger domains. This gene influences signaling pathways that drive epithelial-to-mesenchymal transitions (EMTs) and immune surveillance, which are essential processes in maintaining tissue homeostasis and countering tumor progression. In the respiratory tract, GATA6 is essential for the differentiation of lung epithelial cells, impacting the expression of WNT7B and surfactant proteins, vital for proper lung function. Furthermore, studies suggest that GATA6 contributes to an immune-enriched phenotype linked to favorable prognostic outcomes in certain cancers, indicating its potential role in mitigating metastatic propensity by enhancing immune response and surveillance against tumorous cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ASD9; AVSD5; GATA-binding factor 6; Transcription factor GATA-6
Gene Aliases: GATA6
UniProt ID: (Human) Q92908
Entrez Gene ID: (Human) 2627
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor binding
RNA polymerase II repressing transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription factor binding
zinc ion binding
protein kinase binding
transcription regulatory region DNA binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
liver development
outflow tract septum morphogenesis
type B pancreatic cell differentiation
pancreatic A cell differentiation
transcription from RNA polymerase II promoter
phospholipid metabolic process
endodermal cell fate determination
blood coagulation
male gonad development
cardiac muscle hypertrophy in response to stress
positive regulation of BMP signaling pathway
negative regulation of transforming growth factor beta1 production
negative regulation of transforming growth factor beta2 production
tube morphogenesis
response to drug
negative regulation of apoptotic process
response to estrogen
cellular protein metabolic process
cell fate commitment
positive regulation of angiogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell development
organ formation
smooth muscle cell differentiation
positive regulation of cardioblast differentiation
cardiac muscle cell differentiation
positive regulation of cardiac muscle cell proliferation
lung saccule development
Clara cell differentiation
Type II pneumocyte differentiation
intestinal epithelial cell differentiation
cardiac vascular smooth muscle cell differentiation
response to growth factor
positive regulation of cell cycle arrest
cellular response to gonadotropin stimulus
cellular response to hypoxia
cellular response to BMP stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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