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Invitrogen
GBA Polyclonal Antibody
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FIGURE: 1 / 1
GBA Antibody (PA5-97045) in WB
Western blot analysis of GBA in extracts of MCF-7 cells. Samples were incubated with GBA Polyclonal antibody (Product # PA5-97045) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-97045
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
1.93 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: MCF7; Cellular Location: Lumenal side, Lysosome membrane, Peripheral membrane protein
Target Information
GBA encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acid beta-glucosidase; Alglucerase; Beta-GC; Beta-glucocerebrosidase; Beta-glucosylceramidase 1; Cholesterol glucosyltransferase; Cholesteryl-beta-glucosidase; D-glucosyl-N-acylsphingosine glucohydrolase; glucocerebrosidase; glucocerebrosidase precursor (5' end put.); putative; glucosidase, beta, acid; Glucosylceramidase beta 1; glucosylceramidase-like protein; Imiglucerase; Lysosomal acid GCase; Lysosomal acid glucosylceramidase; Lysosomal cholesterol glycosyltransferase; Lysosomal galactosylceramidase; lysosomal glucocerebrosidase; Lysosomal glycosylceramidase; SGTase; unnamed protein product
Gene Aliases: GBA; GBA1; GC; GCB; GLUC
UniProt ID: (Human) P04062
Entrez Gene ID: (Human) 2629
galactosylceramidase activity
glucosylceramidase activity
receptor binding
scavenger receptor binding
protein binding
beta-glucosidase activity
transferase activity
transferase activity, transferring glycosyl groups
hydrolase activity
hydrolase activity, acting on glycosyl bonds
glucosyltransferase activity
steryl-beta-glucosidase activity
mitophagy
lipid metabolic process
sphingolipid metabolic process
glucosylceramide metabolic process
glucosylceramide catabolic process
autophagy
mitochondrion organization
lysosome organization
central nervous system development
steroid metabolic process
cholesterol metabolic process
determination of adult lifespan
cellular response to starvation
response to pH
negative regulation of macromolecule metabolic process
microglia differentiation
regulation of macroautophagy
antigen processing and presentation
lipid storage
cerebellar Purkinje cell layer formation
pyramidal neuron differentiation
respiratory electron transport chain
termination of signal transduction
lipid glycosylation
neuron projection development
negative regulation of protein complex assembly
regulation of TOR signaling
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of interleukin-6 production
T cell differentiation in thymus
response to testosterone
regulation of protein catabolic process
regulation of membrane potential
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of MAPK cascade
negative regulation of neuron apoptotic process
response to estrogen
sphingosine biosynthetic process
ceramide biosynthetic process
cell maturation
brain morphogenesis
homeostasis of number of cells
negative regulation of inflammatory response
neurological system process
neuromuscular process
regulation of protein metabolic process
positive regulation of protein metabolic process
negative regulation of protein metabolic process
neuron apoptotic process
establishment of skin barrier
microglial cell proliferation
motor behavior
cellular response to tumor necrosis factor
hematopoietic stem cell proliferation
response to dexamethasone
lymphocyte migration
response to thyroid hormone
skin epidermis development
beta-glucoside catabolic process
positive regulation of proteolysis involved in cellular protein catabolic process
positive regulation of neuronal action potential
autophagosome organization
positive regulation of type 2 mitophagy
lysosomal protein catabolic process
regulation of lysosomal protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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