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Invitrogen

GBA Polyclonal Antibody

View all (39) GBA antibodies

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Product Details

PA5-97045

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein (or fragment)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.93 mg/mL

Amount

193 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2808847

Product Specific Information

Positive Samples: MCF7; Cellular Location: Lumenal side, Lysosome membrane, Peripheral membrane protein

Target Information

GBA encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Acid beta-glucosidase; Alglucerase; Beta-GC; Beta-glucocerebrosidase; Beta-glucosylceramidase 1; Cholesterol glucosyltransferase; Cholesteryl-beta-glucosidase; D-glucosyl-N-acylsphingosine glucohydrolase; glucocerebrosidase; glucocerebrosidase precursor (5' end put.); putative; glucosidase, beta, acid; Glucosylceramidase beta 1; glucosylceramidase-like protein; Imiglucerase; Lysosomal acid GCase; Lysosomal acid glucosylceramidase; Lysosomal cholesterol glycosyltransferase; Lysosomal galactosylceramidase; lysosomal glucocerebrosidase; Lysosomal glycosylceramidase; SGTase; unnamed protein product

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Gene Aliases: GBA; GBA1; GC; GCB; GLUC

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UniProt ID: (Human) P04062

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Entrez Gene ID: (Human) 2629

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Function(s)
galactosylceramidase activity glucosylceramidase activity receptor binding scavenger receptor binding protein binding beta-glucosidase activity transferase activity transferase activity, transferring glycosyl groups hydrolase activity hydrolase activity, acting on glycosyl bonds glucosyltransferase activity steryl-beta-glucosidase activity
Process(es)
mitophagy lipid metabolic process sphingolipid metabolic process glucosylceramide metabolic process glucosylceramide catabolic process autophagy mitochondrion organization lysosome organization central nervous system development steroid metabolic process cholesterol metabolic process determination of adult lifespan cellular response to starvation response to pH negative regulation of macromolecule metabolic process microglia differentiation regulation of macroautophagy antigen processing and presentation lipid storage cerebellar Purkinje cell layer formation pyramidal neuron differentiation respiratory electron transport chain termination of signal transduction lipid glycosylation neuron projection development negative regulation of protein complex assembly regulation of TOR signaling positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of interleukin-6 production T cell differentiation in thymus response to testosterone regulation of protein catabolic process regulation of membrane potential proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of MAPK cascade negative regulation of neuron apoptotic process response to estrogen sphingosine biosynthetic process ceramide biosynthetic process cell maturation brain morphogenesis homeostasis of number of cells negative regulation of inflammatory response neurological system process neuromuscular process regulation of protein metabolic process positive regulation of protein metabolic process negative regulation of protein metabolic process neuron apoptotic process establishment of skin barrier microglial cell proliferation motor behavior cellular response to tumor necrosis factor hematopoietic stem cell proliferation response to dexamethasone lymphocyte migration response to thyroid hormone skin epidermis development beta-glucoside catabolic process positive regulation of proteolysis involved in cellular protein catabolic process positive regulation of neuronal action potential autophagosome organization positive regulation of type 2 mitophagy lysosomal protein catabolic process regulation of lysosomal protein catabolic process
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