Proteintech

GBP1 Polyclonal Antibody

GBP1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 8

GBP1 Antibody (15303-1-AP) in ICC/IF

Immunofluorescent analysis of MCF-7 cells, using GBP1 antibody 15303-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

GBP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

GBP1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15303-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 15 publications 15 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GBP1 Fusion Protein Ag7562 (242-592 aa encoded by BC002666)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.41 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: VHRRKLAQL EKLQDEELDP EFVQQVADFC SYIFSNSKTK TLSGGIQVNG PRLESLVLTY VNAISSGDLP CMENAVLALA QIENSAAVQK AIAHYEQQMG QKVQLPTESL QELLDLHRDS EREAIEVFIR SSFKDVDHLF QKELAAQLEK KRDDFCKQNQ EASSDRCSGL LQVIFSPLEE EVKAGIYSKP GGYRLFVQKL QDLKKKYYEE PRKGIQAEEI LQTYLKSKES MTDAILQTDQ TLTEKEKEIE VERVKAESAQ ASAKMLQEMQ RKNEQMMEQK ERSYQEHLKQ LTEKMENDRV QLLKEQERTL ALKLQEQEQL LKEGFQKESR IMKNEIQDLQ TKMRRRKACT IS (242-592 aa encoded by BC002666)

Target Information

GBP1 or guanlyate binding protein 1 is a 68 kDa GTPase and member of the GTPase1 family of molecules. GBP1 expression is induced by Interferon g as well as other inflammatory cytokines including IL-1a, IL-1b and TNF-a. Induction of GBP1 expression by poly I:C, a prototypical TLR3 ligand, as well as GBP1 expression dependency on NF-kB and IFNa response elements implicate TLR pathway involvement. Inversely proportional expression of GBP1 and MMP-1 as well as other related molecules to adhesion and migration show a clear functional role of GBP1 in suppressing angiogenesis and migration especially of endothelial cells. As a regulatory molecule it is centrally involved in signal transduction of inflammatory and cell migration networks.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Journal of immunology research

Ning Y,Lin K,Fang J,Chen X,Hu X,Liu L,Zhao Q,Wang H,Wang F

Tue Feb 07 00:00:00 UTC 2023

Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy.

Cancer cell

Li G,Choi JE,Kryczek I,Sun Y,Liao P,Li S,Wei S,Grove S,Vatan L,Nelson R,Schaefer G,Allen SG,Sankar K,Fecher LA,Mendiratta-Lala M,Frankel TL,Qin A,Waninger JJ,Tezel A,Alva A,Lao CD,Ramnath N,Cieslik M,Harms PW,Green MD,Chinnaiyan AM,Zou W

Mon Feb 13 00:00:00 UTC 2023

CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway.

The international journal of biochemistry & cell biology

Wen C,Li Y,Huang Y,Wang N,He S,Bao M,Zhou H,Wu L

Sun Jan 01 00:00:00 UTC 2023

Knockdown of GBP1 inhibits BCG-induced apoptosis in macrophage RAW 264.7 cells via p38/JNK pathway.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

Wang J,Liu Z,Li W,Yu J,Zhang D

Sat Jan 01 00:00:00 UTC 2022

Knockdown of GBP1 inhibits BCG-induced apoptosis in macrophage RAW 264.7 cells via p38/JNK pathway.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

Wang J,Liu Z,Li W,Yu J,Zhang D

Sat Jan 01 00:00:00 UTC 2022

In vivo interferon-gamma induced changes in gene expression dramatically alter neutrophil phenotype.

PloS one

Ambruso DR,Briones NJ,Baroffio AF,Murphy JR,Tran AD,Gowan K,Sanford B,Ellison M,Jones KL

Wed Mar 16 00:00:00 UTC 2022

Class ¿ histone deacetylase inhibitor regulate of Mycobacteria-Driven guanylate-binding protein 1 gene expression.

Microbial pathogenesis

Wei M,Qin Y,Qian K,Shang S,Zhao Y,Xie T,Xi J,Tang B

Mon Aug 01 00:00:00 UTC 2022

Mechanistic insight into bacterial entrapment by septin cage reconstitution.

Nature communications

Lobato-Márquez D,Xu J,Güler GÖ,Ojiakor A,Pilhofer M,Mostowy S

Fri Jul 23 00:00:00 UTC 2021

Constitutive TRIM22 Expression in the Respiratory Tract Confers a Pre-Existing Defence Against Influenza A Virus Infection.

Frontiers in cellular and infection microbiology

Charman M,McFarlane S,Wojtus JK,Sloan E,Dewar R,Leeming G,Al-Saadi M,Hunter L,Carroll MW,Stewart JP,Digard P,Hutchinson E,Boutell C

Mon Oct 18 00:00:00 UTC 2021

Identification of the interferon-inducible GTPase GBP1 as major restriction factor for the Hepatitis E virus.

Journal of virology

Glitscher M,Himmelsbach K,Woytinek K,Schollmeier A,Johne R,Praefcke GJK,Hildt E

Wed Mar 10 00:00:00 UTC 2021

Identification of the interferon-inducible GTPase GBP1 as major restriction factor for the Hepatitis E virus.

Journal of virology

Glitscher M,Himmelsbach K,Woytinek K,Schollmeier A,Johne R,Praefcke GJK,Hildt E

Wed Mar 10 00:00:00 UTC 2021

LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy.

Nature cell biology

Li G,Kryczek I,Nam J,Li X,Li S,Li J,Wei S,Grove S,Vatan L,Zhou J,Du W,Lin H,Wang T,Subramanian C,Moon JJ,Cieslik M,Cohen M,Zou W

Sat May 01 00:00:00 UTC 2021

Toxoplasma gondii GRA60 is an effector protein that modulates host cell autonomous immunity and contributes to virulence.

Cellular microbiology

Nyonda MA,Hammoudi PM,Ye S,Maire J,Marq JB,Yamamoto M,Soldati-Favre D

Mon Feb 01 00:00:00 UTC 2021

Cross-talk of pyroptosis and tumor immune landscape in lung adenocarcinoma.

Translational lung cancer research

Wang X,Lin W,Liu T,Xu Z,Wang Z,Cao Z,Feng X,Gao Y,He J

Wed Dec 01 00:00:00 UTC 2021

Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms.

Nature immunology

Wandel MP,Kim BH,Park ES,Boyle KB,Nayak K,Lagrange B,Herod A,Henry T,Zilbauer M,Rohde J,MacMicking JD,Randow F

Sat Aug 01 00:00:00 UTC 2020

Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms.

Nature immunology

Wandel MP,Kim BH,Park ES,Boyle KB,Nayak K,Lagrange B,Herod A,Henry T,Zilbauer M,Rohde J,MacMicking JD,Randow F

Sat Aug 01 00:00:00 UTC 2020

GBP1 promotes erlotinib resistance via PGK1‑activated EMT signaling in non‑small cell lung cancer.

International journal of oncology

Cheng L,Gou L,Wei T,Zhang J

Tue Sep 01 00:00:00 UTC 2020

GBP1 promotes erlotinib resistance via PGK1‑activated EMT signaling in non‑small cell lung cancer.

International journal of oncology

Cheng L,Gou L,Wei T,Zhang J

Tue Sep 01 00:00:00 UTC 2020

Immune profiling reveals prognostic genes in high-grade serous ovarian cancer.

Aging

Wu Y,Xia L,Zhao P,Deng Y,Guo Q,Zhu J,Chen X,Ju X,Wu X

Tue Jun 16 00:00:00 UTC 2020

Immune profiling reveals prognostic genes in high-grade serous ovarian cancer.

Aging

Wu Y,Xia L,Zhao P,Deng Y,Guo Q,Zhu J,Chen X,Ju X,Wu X

Tue Jun 16 00:00:00 UTC 2020

Myxovirus resistance protein A inhibits hepatitis C virus replication through JAK-STAT pathway activation.

Archives of virology

Wang H,Xin X,Wang M,Han L,Li J,Hao Y,Zheng C,Shen C

Fri Jun 01 00:00:00 UTC 2018

Myxovirus resistance protein A inhibits hepatitis C virus replication through JAK-STAT pathway activation.

Archives of virology

Wang H,Xin X,Wang M,Han L,Li J,Hao Y,Zheng C,Shen C

Fri Jun 01 00:00:00 UTC 2018

GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8.

Cell host & microbe

Wandel MP,Pathe C,Werner EI,Ellison CJ,Boyle KB,von der Malsburg A,Rohde J,Randow F

Wed Oct 11 00:00:00 UTC 2017

GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8.

Cell host & microbe

Wandel MP,Pathe C,Werner EI,Ellison CJ,Boyle KB,von der Malsburg A,Rohde J,Randow F

Wed Oct 11 00:00:00 UTC 2017

Mcl-1 stabilization confers resistance to taxol in human gastric cancer.

Oncotarget

Shuang W,Hou L,Zhu Y,Li Q,Hu W

Tue Oct 10 00:00:00 UTC 2017

Mcl-1 stabilization confers resistance to taxol in human gastric cancer.

Oncotarget

Shuang W,Hou L,Zhu Y,Li Q,Hu W

Tue Oct 10 00:00:00 UTC 2017

Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance.

Cancer science

Fukumoto M,Amanuma T,Kuwahara Y,Shimura T,Suzuki M,Mori S,Kumamoto H,Saito Y,Ohkubo Y,Duan Z,Sano K,Oguchi T,Kainuma K,Usami S,Kinoshita K,Lee I,Fukumoto M

Wed Oct 01 00:00:00 UTC 2014

Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance.

Cancer science

Fukumoto M,Amanuma T,Kuwahara Y,Shimura T,Suzuki M,Mori S,Kumamoto H,Saito Y,Ohkubo Y,Duan Z,Sano K,Oguchi T,Kainuma K,Usami S,Kinoshita K,Lee I,Fukumoto M

Wed Oct 01 00:00:00 UTC 2014

Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance.

Cancer science

Fukumoto M,Amanuma T,Kuwahara Y,Shimura T,Suzuki M,Mori S,Kumamoto H,Saito Y,Ohkubo Y,Duan Z,Sano K,Oguchi T,Kainuma K,Usami S,Kinoshita K,Lee I,Fukumoto M

Wed Oct 01 00:00:00 UTC 2014

Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance.

Cancer science

Fukumoto M,Amanuma T,Kuwahara Y,Shimura T,Suzuki M,Mori S,Kumamoto H,Saito Y,Ohkubo Y,Duan Z,Sano K,Oguchi T,Kainuma K,Usami S,Kinoshita K,Lee I,Fukumoto M

Wed Oct 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: GBP-1; GTP-binding protein 1; Guanine nucleotide-binding protein 1; guanylate binding protein 1, interferon-inducible; guanylate binding protein 1, interferon-inducible, 67kDa; Guanylate-binding protein 1; huGBP-1; Interferon-induced guanylate-binding protein 1

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Gene Aliases: GBP1

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UniProt ID: (Human) P32455

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Entrez Gene ID: (Human) 2633

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Function(s)

actin binding GTPase activity protein binding GTP binding enzyme binding cytokine binding spectrin binding identical protein binding Hsp90 protein binding heterotrimeric G-protein

Process(es)

regulation of calcium-mediated signaling negative regulation of T cell receptor signaling pathway defense response to virus interferon-gamma-mediated signaling pathway negative regulation of ERK1 and ERK2 cascade negative regulation of substrate adhesion-dependent cell spreading negative regulation of interleukin-2 secretion regulation of protein localization to plasma membrane negative regulation of protein localization to plasma membrane

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GBP1 Polyclonal Antibody

GBP1 Antibody (15303-1-AP) in ICC/IF

Product Details

15303-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

RNA Immunoprecipitation (RIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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