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7TM Antibodies
GCGR Glucagon Receptor Polyclonal Antibody
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FIGURE: 1 / 3
GCGR Glucagon Receptor Antibody (7TM0251N) in WB
Validation of the Glucagon Receptor in transfected HEK293 cells. Native HEK293 cells (MOCK) or HEK293 cells stably expressing the Glucagon Receptor (GCGR) were lysed and immunoblotted with the anti-GCGR antibody (7TM0251N) at a dilution of 1:1,000.
Product Details
7TM0251N
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to c-terminal end of human GCGR.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Glucagon receptors are G-protein coupled receptors for glucagon and play a central role in the regulation of blood glucose levels and glucose homeostatsis. It regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Glucagon receptors also play an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G-proteins) and modulates the activity of down-stream effectors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GL-R; Glucagon receptor
Gene Aliases: GCGR; GGR; GL-R; MVAH
UniProt ID: (Human) P47871
Entrez Gene ID: (Human) 2642
generation of precursor metabolites and energy
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
response to nutrient
regulation of blood pressure
cellular response to starvation
positive regulation of gene expression
glucose homeostasis
response to starvation
regulation of glycogen metabolic process
cellular response to glucagon stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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