PA5-27959 targets GCKR in WB applications and shows reactivity with Human and mouse samples.
The PA5-27959 immunogen is recombinant protein fragment corresponding to a region within amino acids 68 and 493 of Human GCKR.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
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Protein Aliases: FGQTL5; GKRP; Glucokinase regulator; Glucokinase regulatory protein
Gene Aliases: FGQTL5; GCKR; GKRP