FIGURE: 1 / 2
Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, mouse liver.
Predicted reactivity: Mouse (89%), Rat (90%), Dog (92%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GKRP; glucokinase regulator; Glucokinase regulatory protein; hexokinase 4
Gene Aliases: FGQTL5; GCKR; GKRP
Molecular Function: protein-binding activity modulator