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NeoBiotechnologies
GCM2 Monoclonal Antibody (PCRP-GCM2-1B3)
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Product Details
9247-MSM1-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
PCRP-GCM2-1B3
Immunogen
Recombinant human GCM2 protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive Control:HeLa or MCF-7 cells.
Cellular Location: Nucleus.
Target Information
This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chorion-specific transcription factor GCMb; GCM motif protein 2; GCMb; glial cells missing 2; Glial cells missing homolog 2; glial cells missing homolog b; glide/gcm protein homolog; hGCMb; RP3-417M14.3
Gene Aliases: FIH2; GCM2; GCMB; hGCMb; HRPT4
UniProt ID: (Human) O75603
Entrez Gene ID: (Human) 9247
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
protein binding
sequence-specific DNA binding
metal ion binding
sequence-specific double-stranded DNA binding
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cellular calcium ion homeostasis
cellular phosphate ion homeostasis
gliogenesis
positive regulation of transcription from RNA polymerase II promoter
parathyroid gland development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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