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Fabgennix
GCN2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
GCN2-201AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 1600-1700 on human GCN2 protein
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
EIF2AK4 (GCN2) is a metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor-2 in response to low amino acid availability. It plays a role as an activator of the integrated stress response required for adapatation to amino acid starvation. Mutations in the gene lead to pulmonary vennocclusive disease 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GCN2 eIF2alpha kinase; GCN2-like protein; general control nonderepressible 2; unnamed protein product
Gene Aliases: 2610011M03; GCN2; MGCN2; PVOD2
UniProt ID: (Human) Q9P2K8, (Mouse) Q9QZ05
Entrez Gene ID: (Human) 440275, (Rat) 114859, (Mouse) 27103
DNA damage checkpoint
positive regulation of protein phosphorylation
positive regulation of defense response to virus by host
T cell activation involved in immune response
positive regulation of adaptive immune response
regulation of translational initiation
protein phosphorylation
learning
long-term memory
cellular response to starvation
positive regulation of gene expression
regulation of translational initiation by eIF2 alpha phosphorylation
negative regulation of translation
viral translation
endoplasmic reticulum unfolded protein response
negative regulation of translational initiation in response to stress
cellular response to amino acid starvation
cellular response to UV
response to endoplasmic reticulum stress
regulation of translational initiation in response to stress
negative regulation by host of viral genome replication
negative regulation of neuron differentiation
negative regulation of translational initiation
protein autophosphorylation
regulation of feeding behavior
cellular response to cold
positive regulation of translational initiation in response to starvation
GCN2-mediated signaling
positive regulation of long-term synaptic potentiation
neuron projection extension
regulation of cytoplasmic translational initiation in response to stress
response to amino acid starvation
translational initiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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