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Fabgennix
GCN2 Polyclonal Antibody
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Product Details
GCN2-201Y
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Chicken
/ IgY
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 1600-1700 on human GCN2 protein
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
EIF2AK4 (GCN2) is a metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor-2 in response to low amino acid availability. It plays a role as an activator of the integrated stress response required for adapatation to amino acid starvation. Mutations in the gene lead to pulmonary vennocclusive disease 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: eIF-2-alpha kinase GCN2; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2 eIF2alpha kinase; GCN2-like protein; general control nonderepressible 2; mGCN2
Gene Aliases: 2610011M03; EIF2AK4; GCN2; KIAA1338; MGCN2; PVOD2
UniProt ID: (Human) Q9P2K8, (Mouse) Q9QZ05
Entrez Gene ID: (Human) 440275, (Mouse) 27103, (Rat) 114859
tRNA binding
protein serine/threonine kinase activity
eukaryotic translation initiation factor 2alpha kinase activity
ATP binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
eukaryotic initiation factor eIF2 binding
aminoacyl-tRNA synthetase
non-receptor serine/threonine protein kinase
translational protein
positive regulation of defense response to virus by host
adaptive immune response
T cell activation involved in immune response
positive regulation of adaptive immune response
regulation of translational initiation
protein phosphorylation
cell cycle arrest
learning
long-term memory
regulation of translational initiation by eIF2 alpha phosphorylation
viral translation
negative regulation of translational initiation in response to stress
negative regulation of CREB transcription factor activity
cellular response to amino acid starvation
cellular response to UV
eiF2alpha phosphorylation in response to endoplasmic reticulum stress
induction by virus of host autophagy
negative regulation by host of viral genome replication
negative regulation of neuron differentiation
negative regulation of translational initiation
protein autophosphorylation
defense response to virus
regulation of feeding behavior
regulation of eIF2 alpha phosphorylation by amino acid starvation
cellular response to cold
positive regulation of translational initiation in response to starvation
positive regulation of long-term synaptic potentiation
neuron projection extension
cellular response to leucine starvation
cellular response to starvation
positive regulation of gene expression
phosphorylation
negative regulation of translation
endoplasmic reticulum unfolded protein response
response to endoplasmic reticulum stress
regulation of translational initiation in response to stress
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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