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Invitrogen
GDF15 Polyclonal Antibody
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FIGURE: 1 / 4
GDF15 Antibody (42-1700) in ICC/IF
Immunofluorescence analysis of GDF15 was performed using 70% confluent log phase HCT 116 cells treated with 1 µm of Thapsigargin for 16 hours and PTI. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with GDF15 Polyclonal Antibody (Product # 42-1700) at 5 µg/mL in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Seconda... View More
Product Details
42-1700
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from the N-terminal region of the human GDF-15 protein
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
GDF-15 belongs to the TGF-beta cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest GDF-15's involvement in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GDF-15; Growth/differentiation factor 15; Macrophage inhibitory cytokine 1; MIC-1; NAG-1; NAG1; non-steroidal anti-inflammatory drug-activated gene-1; NRG-1; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; PDF; Placental bone morphogenetic protein; Placental TGF-beta; Prostate differentiation factor; PTGF-beta; TGF-b superfamily cytokine; unnamed protein product
Gene Aliases: GDF-15; GDF15; HG; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB
UniProt ID: (Human) Q99988
Entrez Gene ID: (Human) 9518
reduction of food intake in response to dietary excess
negative regulation of leukocyte migration
signal transduction
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
cell-cell signaling
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of appetite
negative regulation of multicellular organism growth
positive regulation of MAPK cascade
positive regulation of fatty acid oxidation
positive regulation of protein kinase B signaling
negative regulation of SMAD protein import into nucleus
negative regulation of growth hormone receptor signaling pathway
cellular response to chemical stress
energy homeostasis
GDF15-GFRAL signaling pathway
response to metformin
positive regulation of myoblast fusion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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