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GDF6 Polyclonal Antibody
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Product Details
BS-11843R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human GDF6, amino acids 336-410.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
GDF6 is a growth differentiation factor (GDFs), which are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. Both GDF6 and GDF7 are closely related to GDF5 which has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. In Xenopus, GDF6 is expressed at the edge of the neural plate and within the anterior neural plate including the eye fields. GDF6 is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. It may regulate patterning of the ectoderm by interacting with bone morphogenetic proteins (BMPs), and control eye development. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), a congenital disorder of spinal segmentation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP-13; Bone morphogenetic protein 13; GDF-6; growth differentiation factor 16; Growth/differentiation factor 16; Growth/differentiation factor 6
Gene Aliases: BMP-13; BMP13; CDMP2; Gdf-6; GDF16; GDF6; KFM; KFS; KFS1; KFSL; SGM1; SYNS4
UniProt ID: (Human) Q6KF10, (Rat) Q6HA10, (Mouse) P43028
Entrez Gene ID: (Human) 392255, (Rat) 252834, (Mouse) 242316
metanephros development
apoptotic process
epithelial cell migration
BMP signaling pathway
positive regulation of chondrocyte differentiation
activin receptor signaling pathway
cell migration involved in metanephros development
fat cell differentiation
positive regulation of cell differentiation
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of SMAD protein import into nucleus
positive regulation of p38MAPK cascade
retinal cell apoptotic process
positive regulation of pathway-restricted SMAD protein phosphorylation
growth
regulation of apoptotic process
regulation of MAPK cascade
cell development
pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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