Rockland

GDNF Polyclonal Antibody

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Datasheet
Protocols
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Datasheet
Protocols
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Tech Support

Product Details

600-401-R08

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GDNF affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human GDNF.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide, 0.05mg thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Astrocyte-derived trophic factor; ATF; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; Glial cell line-derived neurotrophic factor; H-GDNF; hGDNF

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Gene Aliases: ATF1; ATF2; GDNF; gndf; HFB1-GDNF; HSCR3

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UniProt ID: (Human) P39905, (Rat) Q07731

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Entrez Gene ID: (Human) 2668, (Rat) 25453

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Function(s)
Ras guanyl-nucleotide exchange factor activity receptor binding protein binding growth factor activity protein homodimerization activity glial cell-derived neurotrophic factor receptor binding neurotrophic factor
Process(es)
MAPK cascade metanephros development branching involved in ureteric bud morphogenesis neural crest cell migration organ induction postsynaptic membrane organization mesenchymal to epithelial transition involved in metanephros morphogenesis signal transduction nervous system development positive regulation of cell proliferation adult locomotory behavior regulation of gene expression postganglionic parasympathetic fiber development peristalsis neuron projection development positive regulation of monooxygenase activity positive regulation of dopamine secretion negative regulation of apoptotic process negative regulation of neuron apoptotic process positive regulation of GTPase activity positive regulation of cell differentiation positive regulation of transcription from RNA polymerase II promoter mRNA stabilization enteric nervous system development sympathetic nervous system development regulation of dopamine uptake involved in synaptic transmission ureteric bud formation regulation of morphogenesis of a branching structure positive regulation of ureteric bud formation positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis positive regulation of branching involved in ureteric bud morphogenesis regulation of stem cell differentiation negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ureteric bud development peripheral nervous system development cell proliferation male gonad development response to wounding neuron differentiation midbrain development retina development in camera-type eye cellular response to dexamethasone stimulus regulation of ureteric bud formation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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