Search
Invitrogen
GDNF Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 1
GDNF Antibody (PA1-18359) in IHC
mBio 2020 -
FIG 6 GDNF mRNA and protein levels were significantly higher in the duodenum of rotavirus-infected mice. (A) The duodenum of infected ( n = 8) and noninfected ( n = 7) mouse pups were collected at 16 h p.i., and the Gdnf and TATA-binding protein ( Tbp ) mRNA levels were quantified using qPCR. There was significant upregulation of Gdnf mRNA in the infected mice. Data are means +- SEM. * , P < 0.05, unpaired ... View More
Product Details
PA1-18359
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant human GDNF (aa 78-211).
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Target Information
GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Astrocyte-derived trophic factor; ATF; GDNF; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; Glial cell line-derived neurotrophic factor; H-GDNF; hGDNF; mGDNF; neurotrophic factor
Gene Aliases: AI385739; ATF; ATF1; ATF2; GDNF; gndf; HFB1-GDNF; HSCR3
UniProt ID: (Human) P39905, (Mouse) P48540, (Rat) Q07731
Entrez Gene ID: (Human) 2668, (Mouse) 14573, (Rat) 25453
metanephros development
ureteric bud development
branching involved in ureteric bud morphogenesis
neural crest cell migration
organ induction
postsynaptic membrane organization
mesenchymal to epithelial transition involved in metanephros morphogenesis
signal transduction
nervous system development
peripheral nervous system development
positive regulation of cell proliferation
adult locomotory behavior
tissue development
regulation of gene expression
dorsal spinal cord development
postganglionic parasympathetic fiber development
neuron differentiation
peristalsis
neuron projection development
positive regulation of dopamine secretion
glial cell-derived neurotrophic factor receptor signaling pathway
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
regulation of cell differentiation
positive regulation of cell differentiation
positive regulation of transcription from RNA polymerase II promoter
mRNA stabilization
enteric nervous system development
sympathetic nervous system development
animal organ development
embryonic organ development
regulation of dopamine uptake involved in synaptic transmission
ureteric bud formation
regulation of morphogenesis of a branching structure
chemoattraction of axon
commissural neuron axon guidance
positive regulation of ureteric bud formation
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
positive regulation of branching involved in ureteric bud morphogenesis
regulation of stem cell differentiation
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
regulation of semaphorin-plexin signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
cell proliferation
response to wounding
positive regulation of monooxygenase activity
cellular response to dexamethasone stimulus
regulation of ureteric bud formation
male gonad development
midbrain development
retina development in camera-type eye
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support