GFI1 is a nuclear zinc finger (ZF) transcriptional repressor that plays an important role in hematopoiesis and inner ear development, and has been implicated in lymphomagenesis. The Gfi1 protein expression is regulated by the ubiquitin-proteasome system. It is reported that ubiquitin ligase Triad1 interacts with the DNA-binding domain of Gfi-1. Gfi-1 represses transcription by directly binding to the consensus DNA sequence in the promoters of its target genes. Deficiency of Gfi-1 causes neutropenia and an accumulation of granulomonocytic precursor cells that is reminiscent of a myelodysplastic syndrome in mice.
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Protein Aliases: FLJ94509; growth factor independence-1; growth factor independent 1 transcription repressor; Growth factor independent protein 1; Growth factor independent-1; Zinc finger protein 163; Zinc finger protein Gfi-1
Gene Aliases: AW495828; GFI-1; GFI1; GFI1A; Pal-1; Pal1; SCN2; ZNF163