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|Tested species reactivity||Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues P(376) R V E K T P S L P D D L S D(390) of human GFR alpha-2.|
|Storage buffer||whole serum|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-18399 detects GFR alpha-2 from rat samples.
PA1-18399 has been successfully used in immunohistochemistry and Western blot procedures.
The PA1-18399 immunogen is a synthetic peptide corresponding to residues P(376) R V E K T P S L P D D L S D(390) of human GFR alpha-2, conjugated to KLH.
Reconstitute with 100 ul of distilled water.
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
GDNF family receptor alpha-2; GDNF re; GFR-alpha-2; glial cell line derived neurotrophic factor family receptor alpha 2; NRTNR-alpha; NTNR-alpha; tyrosine kinase receptor ligand 2