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Abnova
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FIGURE: 1 / 2
Sequence of this protein is as follows: MEPAMEPETL EARINRATNP LNKELDWASI NGFCEQLNED FEGPPLATRL LAHKIQSPQE WEAIQALTVL ETCMKSCGKR FHDEVGKFRF LNELIKVVSP KYLGSRTSEK VKNKILELLY SWTVGLPEEV KIAEAYQMLK KQGIVKSDPK LPDDTTFPLP PPRPKNVIFE DEEKSKMLAR LLKSSHPEDL RAANKLIKEM VQEDQKRMEK ISKRVNAIEE VNNNVKLLTE MVMSHSQGGA AAGSSEDLMK ELYQRCERMR PTLFRLASDT EDNDEALGLS DPTPPSGPSL DGTGWNSFQS SDATEPPAPA LAQAPSMESR PPAQTSLPAS SGLDDLDLLG KTLLQQSLPP ESQQVRWEKQ QPTPRLTLRD LQNKSSSCSS PSSSATSLLH TVSPEPPRPP QQPVPTELSL ASITVPLESI KPSNILPVTV YDQHGFRILF HFARDPLPGR SDVLVVVVSM LSTAPQPIRN IVFQSAVPKV MKVKLQPPSG TELPAFNPIV HPSAITQVLL LANPQKEKVR LRYKLTFTMG DQTYNEMGDV DQFPPPETWG SL
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
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