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Proteintech

GHRL Polyclonal Antibody

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View all (27) Ghrelin antibodies

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GHRL Polyclonal Antibody

Product Details

13309-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:1,000
View 3 publications 3 publications

Immunohistochemistry (IHC)

-
View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:800
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GHRL Fusion Protein Ag4141 (28-117 aa encoded by BC025791)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Amount

40.5 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LSPEHQRVQ QRKESKKPPA KLQPRALAGW LRPEDGGQAE GAEDEMEVRF NAPFDVGIKL SGVQYQQHSQ ALGKFLQDIL WEEAKEAPAD K (28-117 aa encoded by BC025791)

Target Information

GHRL encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an the ligand for the growth hormone secretagogue receptor type 1 and is involved in regulating growth hormone release. Ghrelin has an appeptite-stimulating effect and induces adiposity and stimulates gastric acid secretion. Obestatin may be the ligand for the orphan G protein-coupled receptor GPR39 and is involved in satiety and can have an appetite-reducing effect resulting in decreased food intake.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: AMCBX1; appetite-regulating hormone isoform In2c; FIP-3; FIP3; Fip3p; ghrelin 27; ghrelin 28; ghrelin, growth hormone secretagogue receptor ligand; ghrelin/obestatin; ghrelin/obestatin preprohormone; ghrelin/obestatin prepropeptide; growth hormone secretagogue; growth hormone-releasing peptide; IKK-gamma; In2c-preproghrelin; IP; IP1; IP2; IPD2; motilin-related peptide; NEMO; OTTHUMP00000207794; OTTHUMP00000207795; OTTHUMP00000207796; OTTHUMP00000207798; prepro-appetite regulatory hormone; preproghrelin; proghrelin; unnamed protein product

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Gene Aliases: 2210006E23Rik; Ghr; m46; MTLRP; MTLRPAP

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UniProt ID: (Human) Q9UBU3, (Mouse) Q9EQX0, (Rat) Q9QYH7

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Entrez Gene ID: (Human) 51738, (Mouse) 58991, (Rat) 59301

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Function(s)
hormone activity protein binding growth hormone-releasing hormone activity protein tyrosine kinase activator activity ghrelin receptor binding G-protein coupled receptor binding
Process(es)
gastric acid secretion negative regulation of endothelial cell proliferation G-protein coupled receptor internalization G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration actin polymerization or depolymerization adult feeding behavior visual learning response to hormone hormone-mediated signaling pathway dendrite development positive regulation of insulin secretion regulation of response to food positive regulation of response to food positive regulation of appetite negative regulation of interleukin-1 beta production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of growth rate negative regulation of locomotion regulation of cell proliferation negative regulation of circadian sleep/wake cycle, REM sleep negative regulation of apoptotic process positive regulation of MAPK cascade response to estrogen positive regulation of growth positive regulation of circadian sleep/wake cycle, non-REM sleep negative regulation of insulin secretion decidualization negative regulation of inflammatory response positive regulation of corticotropin secretion positive regulation of cortisol secretion positive regulation of synapse assembly regulation of transmission of nerve impulse excitatory postsynaptic potential positive regulation of growth hormone secretion postsynaptic modulation of chemical synaptic transmission regulation of postsynapse organization positive regulation of small intestinal transit positive regulation of cold-induced thermogenesis positive regulation of bone development positive regulation of sprouting angiogenesis positive regulation of eating behavior positive regulation of adipose tissue development positive regulation of gastro-intestinal system smooth muscle contraction positive regulation of gastric mucosal blood circulation positive regulation of small intestine smooth muscle contraction regulation of gastric motility positive regulation of vascular endothelial cell proliferation positive regulation of feeding behavior response to nutrient levels response to electrical stimulus glucose metabolic process negative regulation of angiogenesis growth hormone secretion positive regulation of multicellular organism growth cortisol secretion cartilage development positive regulation of growth hormone receptor signaling pathway
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