Immunogen sequence: MDLVKNHLMY AVREEVEILK EQIRELVEKN SQLERENTLL KTLASPEQLE KFQSCLSPEE PAPESPQVPE APGGSAV; Positive Samples: 293T, Mouse spleen; Cellular Location: Cytoplasm, Nucleus
This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants.
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Protein Aliases: delta sleep inducing peptide, immunoreactor; Delta sleep-inducing peptide immunoreactor; DSIP-immunoreactive leucine zipper protein; DSIP-immunoreactive peptide; GILZ; Glucocorticoid-induced leucine zipper protein; long glucocorticoid-induced leucine zipper protein; Protein DIP; Tilz3; TSC-22 related protein; TSC-22-like protein; TSC-22-related protein; TSC-22R; TSC22 domain family 3; TSC22 domain family protein 3; TSC22 domain family, member 3; TSC22-related inducible leucine zipper 3; TSC22-related-inducible leucine zipper 3
Gene Aliases: DIP; Dsip1; DSIPI; GILZ; Tilz3; TSC-22R; TSC22D3
Molecular Function: transcription factor