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Proteintech
GIPR Polyclonal Antibody
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Product Details
28322-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GIPR Fusion Protein Ag28143
Conjugate
Form
Liquid
Concentration
267 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
GIPR encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Gastric inhibitory polypeptide receptor; GIP receptor; GIP-R; Glucose-dependent insulinotropic polypeptide receptor
Gene Aliases: GIP-R; GIPR; Gm1081; Gm160; PGQTL2
UniProt ID: (Human) P48546, (Mouse) Q0P543
Entrez Gene ID: (Human) 2696, (Mouse) 381853
desensitization of G-protein coupled receptor protein signaling pathway
generation of precursor metabolites and energy
cell surface receptor signaling pathway
activation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
response to nutrient
response to glucose
endocrine pancreas development
positive regulation of insulin secretion
gastric inhibitory peptide signaling pathway
response to axon injury
regulation of insulin secretion
response to calcium ion
response to fatty acid
signal transduction
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
positive regulation of cAMP biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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