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Proteintech
GLTSCR2 Polyclonal Antibody
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Product Details
27353-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GLTSCR2 Fusion Protein Ag26358 (141-440 aa encoded by BC010095)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: NAKKLRRKE QLWEKLAKQG ELPREVRRAQ ARLLNPSATR AKPGPQDTVE RPFYDLWASD NPLDRPLVGQ DEFFLEQTKK KGVKRPARLH TKPSQAPAVE VAPAGASYNP SFEDHQTLLS AAHEVELQRQ KEAEKLERQL ALPATEQAAT QESTFQELCE GLLEESDGEG EPGQGEGPEA GDAEVCPTPA RLATTEKKTE QQRRREKAVH RLRVQQAALR AARLRHQELF RLRGIKAQVA LRLAELARRR RRRQARREAE ADKPRRLGRL KYQAPDIDVQ LSSELTDSLR TLKPEGNILR D (141-440 aa encoded by BC010095)
Target Information
Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription. Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation. It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation. Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway. May also inhibit cell proliferation and increase apoptosis through its interaction with NF2. May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation. Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex. May also regulate cellular aerobic respiration. In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of DDX58/RIG-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Glioma tumor suppressor candidate region gene 2 protein; p60; PICT-1; Protein interacting with carboxyl terminus 1; Ribosome biogenesis protein NOP53
Gene Aliases: GLT; GLTSCR2; NOP53; PICT-1; PICT1
UniProt ID: (Human) Q9NZM5
Entrez Gene ID: (Human) 29997
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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