PA1-1065 detects GLUT4 in rat samples.
PA1-1065 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~46 kDa protein representing GLUT4 in rat heart samples.
The PA1-1065 immunogen is a synthetic peptide corresponding to residues E(493) Q E V K P S T E L E Y L G P D E N D(509) of rat GLUT4. The PA1-1065 immunizing peptide (Cat. # PEP-283) is available for use in neutralization and control experiments.
The stimulation of glucose uptake by insulin in muscle and adipose tissue requires translocation of the GLUT4 (Glucose transporter type 4, insulin-responsive) glucose transporter from intracellular storage sites to the cell surface. Insulin stimulates glucose transport by promoting translocation of GLUT4 proteins from the perinuclear compartment to the cell surface. Human insulin resistance involves a defect in GLUT4 traffic and targeting leading to accumulation in a dense membrane compartment from which insulin is unable to recruit GLUT4 to the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Glucose transporter 4 insuline-responsive; Glucose transporter 4, insuline-responsive; Glucose transporter type 4; Glucose transporter type 4, insulin-responsive; GLUT-4; insulin responsive glucose transporter; insulin-responsive; solute carrier family 2 member 4; solute carrier family 2 , member 4; Solute carrier family 2, facilitated glucose transporter member 4
Gene Aliases: Glut-4; Glut4; Slc2a4
UniProt ID: (Rat) P19357
Entrez Gene ID: (Rat) 25139