Recommended positive controls: HeLa, mouse kidney, rat brain.
Predicted reactivity: Mouse (99%), Rat (98%), Xenopus laevis (97%), Dog (99%), Pig (97%), Chicken (100%), Rhesus Monkey (100%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of α, β and γ subunits and mediate the effects of hormones, neurotransmitters, chemokines and sensory stimuli. To date, over 20 known Gα subunits have been classified into four families, Gα(s), Gα(i/o), Gα(q) and Gα(12), based on structural and functional similarities (1,2). Phosphorylation of Tyr356 of Gα(q)/Gα(11) is essential for activation of the G protein, since phenylalanine substitution for Tyr356 changes the interaction of Gα with receptors and abolishes ligand-induced IP3 formation (3).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: G alpha-11; G-protein subunit alpha-11; GNA-11; GNA11; Gq class; guanine nucleotide binding protein (G protein), alpha 11 (Gq class); guanine nucleotide regulatory protein G alpha 11; guanine nucleotide-binding protein; guanine nucleotide-binding protein alpha 11 subunit; Guanine nucleotide-binding protein G(y) subunit alpha; Guanine nucleotide-binding protein subunit alpha-11
Gene Aliases: Dsk7; E430025L19; FBH; FBH2; FHH2; GA11; GNA-11; GNA11; HHC2; HYPOC2