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Invitrogen
GNA11 Polyclonal Antibody
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FIGURE: 1 / 6
GNA11 Antibody (PA5-76678) in IHC (P)
Immunohistochemistry analysis of GNA11 in paraffin-embedded human esophageal cancer. Samples were incubated with GNA11 polyclonal antibody (Product # PA5-76678) using a dilution of 1:150. Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-76678
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length Human GNA11.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of α, β and γ subunits and mediate the effects of hormones, neurotransmitters, chemokines and sensory stimuli. To date, over 20 known Gα subunits have been classified into four families, Gα(s), Gα(i/o), Gα(q) and Gα(12), based on structural and functional similarities (1,2). Phosphorylation of Tyr356 of Gα(q)/Gα(11) is essential for activation of the G protein, since phenylalanine substitution for Tyr356 changes the interaction of Gα with receptors and abolishes ligand-induced IP3 formation (3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G alpha-11; G protein; G-protein subunit alpha-11; G11; GNA11; Gq class; guanine nucleotide binding protein (G protein), alpha 11 (Gq class); guanine nucleotide regulatory protein G alpha 11; guanine nucleotide-binding protein alpha 11 subunit; Guanine nucleotide-binding protein G(y) subunit alpha; Guanine nucleotide-binding protein subunit alpha-11; heterotrimeric guanine nucleotide-binding protein 1K
Gene Aliases: Dsk7; E430025L19; FBH; FBH2; FHH2; GA11; GNA-11; GNA11; HG1K; HHC2; HYPOC2
UniProt ID: (Human) P29992, (Mouse) P21278, (Rat) Q9JID2
Entrez Gene ID: (Human) 2767, (Mouse) 14672, (Rat) 81662
nucleotide binding
G-protein coupled receptor binding
GTPase activity
obsolete small monomeric GTPase activity
protein binding
GTP binding
hydrolase activity
guanyl nucleotide binding
enzyme regulator activity
G-protein beta/gamma-subunit complex binding
metal ion binding
signal transducer activity
type 2A serotonin receptor binding
protein complex binding
heterotrimeric G-protein
skeletal system development
action potential
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating serotonin receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
heart development
phototransduction, visible light
regulation of blood pressure
entrainment of circadian clock
positive regulation of insulin secretion
regulation of melanocyte differentiation
developmental pigmentation
phospholipase C-activating dopamine receptor signaling pathway
cellular response to pH
endothelin receptor signaling pathway
cranial skeletal system development
ligand-gated ion channel signaling pathway
glutamate receptor signaling pathway
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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