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Proteintech
GNAO1 Polyclonal Antibody
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Product Details
12635-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GNAO1 Fusion Protein Ag3330 (1-302 aa encoded by BC030027)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Amount
33 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MKIIHEDGF SGEDVKQYKP VVYSNTIQSL AAIVRAMDTL GIEYGDKERK ADAKMVCDVV SRMEDTEPFS AELLSAMMRL WGDSGIQECF NRSREYQLND SAKYYLDSLD RIGAADYQPT EQDILRTRVK TTGIVETHFT FKNLHFRLFD VGGQRSERKK WIHCFEDVTA IIFCVALSGY DQVLHEDETT NRMHESLMLF DSICNNKFFI DTSIILFLNK KDLFGEKIKK SPLTICFPEY TGPNTYEDAA AYIQAQFESK NRSPNKEIYC HMTCATDTNN IQVVFDAVTD IIIANNLRGC GLY (1-302 aa encoded by BC030027)
Target Information
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp686O0962; G alpha o; G protein; GNAO 1; Go alpha; GO2-q chimeric G-protein; GTP-binding protein alpha o; GTP-binding protein alpha-o subunit; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; guanine nucleotide binding protein, alpha O polypeptide 1; Guanine nucleotide-binding protein G(o) subunit alpha; guanine nucleotide-binding regulatory protein 2; heterotrimeric guanine nucleotide-binding protein 1G; unnamed protein product
Gene Aliases: alphaO; AW050213; DEE17; EIEE17; G-ALPHA-o; Galphao; Gna0; GNAO; GNAO1; HG1G; HLA-DQB1; NEDIM; RATBPGTPC
UniProt ID: (Human) P09471, (Rat) P59215, (Mouse) P18872
Entrez Gene ID: (Human) 2775, (Rat) 50664, (Mouse) 14681
nucleotide binding
GTPase activity
obsolete small monomeric GTPase activity
protein binding
GTP binding
adenylate cyclase regulator activity
hydrolase activity
guanyl nucleotide binding
G-protein beta/gamma-subunit complex binding
G-protein coupled serotonin receptor binding
mu-type opioid receptor binding
metal ion binding
corticotropin-releasing hormone receptor 1 binding
signal transducer activity
GDP binding
protein complex binding
GTPase activating protein binding
heterotrimeric G-protein
vesicle docking involved in exocytosis
muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting serotonin receptor signaling pathway
dopamine receptor signaling pathway
locomotory behavior
regulation of heart contraction
negative regulation of insulin secretion
postsynaptic modulation of chemical synaptic transmission
aging
metabolic process
cellular process
response to organonitrogen compound
response to organic cyclic compound
forebrain development
neuron projection development
response to cytokine
response to drug
response to hydrogen peroxide
response to morphine
positive regulation of GTPase activity
negative regulation of calcium ion transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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