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Proteintech
GNAS Polyclonal Antibody
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Product Details
10150-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GNAS Fusion Protein Ag0197 (230-394 aa encoded by BC002722)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Amount
25.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ERRKWIQCF NDVTAIIFVV ASSSYNMVIR EDNQTNRLQE ALNLFKSIWN NRWLRTISVI LFLNKQDLLA EKVLAGKSKI EDYFPEFARY TTPEDATPEP GEDPRVTRAK YFIRDEFLRI STASGDGRHY CYPHFTCAVD TENIRRVFND CRDIIQRMHL RQYELL (230-394 aa encoded by BC002722)
Target Information
Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseous heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. This gene has a highly complex imprinted expression pattern. It encodes maternally, paternally, and biallelically expressed proteins which are derived from alternatively spliced transcripts with alternate 5' exons. Each of the upstream exons is within a differentially methylated region, commonly found in imprinted genes. However, the close proximity (14 kb) of two oppositely expressed promoter regions is unusual. In addition, one of the alternate 5' exons introduces a frameshift relative to the other transcripts, resulting in one isoform which is structurally unrelated to the others. An antisense transcript exists, and may regulate imprinting in this region. Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal dominant inheritance pattern requiring maternal transmission for full penetrance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Adenylate cyclase-stimulating G alpha protein; Alternative gene product encoded by XL-exon; dJ309F20.1.1; dJ806M20.3.3; Extra large alphas protein; G protein; G protein subunit alpha S; G-alpha-8; GNAS; GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus; gnas {ECO:0000312|RGD:2716}; GNSA1; Gs alpha subunit; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide binding protein alpha s; guanine nucleotide regulatory protein; guanine nucleotide-binding protein alpha subunit; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; guanine nucleotide-binding protein G-s, alpha subunit; MGC33735; NESP55; NESP55; large dense core vesicle secretory protein; Neuroendocrine secretory protein 55; OTTHUMP00000031742; OTTHUMP00000196026; OTTHUMP00000196030; PHP1C; Protein ALEX; RP4-543J19.4; secretogranin VI; stimulatory G-protein alpha subunit; unnamed protein product; XLalphas; XLas
Gene Aliases: 5530400H20Rik; A930027G11Rik; AHO; AIMAH1; C130027O20Rik; C20orf45; Galphas; GNAS; GNAS1; Gnasxl; Gnpas; GPSA; GSA; GSP; MNCb-5546; NESP; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2; P3; PHP1A; PHP1B; PITA3; POH; SCG6; SgVI
UniProt ID: (Human) Q5JWF2, (Mouse) Q6R0H7, (Rat) P63095
Entrez Gene ID: (Human) 2778, (Mouse) 14683, (Rat) 24896
nucleotide binding
GTPase activity
obsolete small monomeric GTPase activity
insulin-like growth factor receptor binding
protein binding
GTP binding
adenylate cyclase regulator activity
adenylate cyclase activator activity
hydrolase activity
guanyl nucleotide binding
G-protein beta/gamma-subunit complex binding
beta-2 adrenergic receptor binding
D1 dopamine receptor binding
mu-type opioid receptor binding
ionotropic glutamate receptor binding
metal ion binding
corticotropin-releasing hormone receptor 1 binding
G-protein alpha-subunit binding
signal transducer activity
protein domain specific binding
G-protein beta-subunit binding
alpha-tubulin binding
heterotrimeric G-protein
negative regulation of inflammatory response to antigenic stimulus
renal water homeostasis
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
adenylate cyclase-activating dopamine receptor signaling pathway
adenylate cyclase-activating serotonin receptor signaling pathway
female pregnancy
sensory perception of chemical stimulus
sensory perception of smell
protein secretion
regulation of signal transduction
regulation of skeletal muscle contraction
response to prostaglandin E
negative regulation of multicellular organism growth
intracellular transport
developmental growth
positive regulation of phagocytosis
regulation of insulin secretion
cognition
bone development
hair follicle placode formation
platelet aggregation
response to parathyroid hormone
cellular response to glucagon stimulus
cellular response to prostaglandin E stimulus
cellular response to acidic pH
cellular response to catecholamine stimulus
adenylate cyclase-activating adrenergic receptor signaling pathway
vascular endothelial cell response to laminar fluid shear stress
positive regulation of cold-induced thermogenesis
skeletal system development
tissue homeostasis
positive regulation of protein phosphorylation
endochondral ossification
energy reserve metabolic process
DNA methylation
regulation of transcription from RNA polymerase II promoter
post-embryonic development
positive regulation of sodium ion transport
positive regulation of cAMP biosynthetic process
embryonic hindlimb morphogenesis
multicellular organism growth
negative regulation of renal sodium excretion
post-embryonic body morphogenesis
response to drug
positive regulation of GTPase activity
skin development
positive regulation of cAMP-mediated signaling
positive regulation of osteoblast differentiation
positive regulation of osteoclast differentiation
negative regulation of blood pressure
embryonic cranial skeleton morphogenesis
cartilage development
calcium ion homeostasis
genetic imprinting
metabolic process
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