Invitrogen

GNAS Polyclonal Antibody

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GNAS Polyclonal Antibody

Product Details

PA5-42230

Applications
Tested Dilution
Publications

Western Blot (WB)

1-3 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

4-8 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide directed towards the N-terminal of human GNAS
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS with 2% sucrose

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2609911

Product Specific Information

Peptide sequence: SGKSTIVKQM RILHVNGFNG DSEKATKVQD IKNNLKEAIE TIVAAMSNLV

Sequence homology: Cow: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%

Target Information

Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseous heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. This gene has a highly complex imprinted expression pattern. It encodes maternally, paternally, and biallelically expressed proteins which are derived from alternatively spliced transcripts with alternate 5' exons. Each of the upstream exons is within a differentially methylated region, commonly found in imprinted genes. However, the close proximity (14 kb) of two oppositely expressed promoter regions is unusual. In addition, one of the alternate 5' exons introduces a frameshift relative to the other transcripts, resulting in one isoform which is structurally unrelated to the others. An antisense transcript exists, and may regulate imprinting in this region. Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal dominant inheritance pattern requiring maternal transmission for full penetrance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Adenylate cyclase-stimulating G alpha protein; Alternative gene product encoded by XL-exon; dJ309F20.1.1; dJ806M20.3.3; Extra large alphas protein; G protein subunit alpha S; Gs alpha subunit; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide regulatory protein; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; MGC33735; NESP55; neuroendocrine secretory protein; Neuroendocrine secretory protein 55; OTTHUMP00000031742; OTTHUMP00000196026; OTTHUMP00000196030; PHP1C; Protein ALEX; RP4-543J19.4; secretogranin VI; stimulatory G-protein alpha subunit; XLalphas; XLas

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Gene Aliases: 5530400H20Rik; A930027G11Rik; AHO; C130027O20Rik; C20orf45; Galphas; GNAS; GNAS1; Gnasxl; GPSA; GSA; GSP; MNCb-5546; NESP; Nespl; Oed-Sml; Oedsml; P1; P2; P3; PHP1A; PHP1B; POH; SCG6; SgVI

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UniProt ID: (Human) P84996, (Mouse) Q6R0H6

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Entrez Gene ID: (Human) 2778, (Mouse) 14683

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Function(s)
GTPase activity signal transducer activity insulin-like growth factor receptor binding protein binding GTP binding G-protein beta/gamma-subunit complex binding beta-2 adrenergic receptor binding D1 dopamine receptor binding mu-type opioid receptor binding ionotropic glutamate receptor binding metal ion binding corticotropin-releasing hormone receptor 1 binding nucleotide binding G-protein alpha-subunit binding guanyl nucleotide binding protein domain specific binding G-protein beta-subunit binding alpha-tubulin binding heterotrimeric G-protein
Process(es)
tissue homeostasis endochondral ossification energy reserve metabolic process DNA methylation adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway sensory perception of chemical stimulus embryonic hindlimb morphogenesis multicellular organism growth post-embryonic body morphogenesis response to drug positive regulation of osteoblast differentiation positive regulation of osteoclast differentiation developmental growth embryonic cranial skeleton morphogenesis cognition cartilage development bone development hair follicle placode formation platelet aggregation genetic imprinting regulation of parathyroid hormone secretion skeletal system development positive regulation of protein phosphorylation regulation of transcription from RNA polymerase II promoter signal transduction G-protein coupled receptor signaling pathway post-embryonic development regulation of signal transduction positive regulation of sodium ion transport positive regulation of cAMP biosynthetic process negative regulation of renal sodium excretion negative regulation of multicellular organism growth positive regulation of GTPase activity skin development positive regulation of cAMP-mediated signaling negative regulation of blood pressure calcium ion homeostasis response to parathyroid hormone cellular response to prostaglandin E stimulus cellular response to catecholamine stimulus adenylate cyclase-activating adrenergic receptor signaling pathway
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