This Antibody was verified by Cell Treatment to ensure that the antibody binds to the antigen stated. View Details
A suggested positive control is rat brain tissue lysate.
PA5-20524 can be used with blocking peptide PEP-0644.
Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.
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Protein Aliases: glycerol 3-phosphate acyltransferase, mitochondrial; Glycerol-3-phosphate acyltransferase 1, mitochondrial; GPAT; GPAT-1; P90; RP11-426E5.2, GPAT, GPAT1
Gene Aliases: GPAM; GPAT; GPAT1; KIAA1560