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GPLD1 Polyclonal Antibody
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Product Details
BS-9910R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human GPLD1/GPI-PLD.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
GPLD1 is expressed in numerous tissues and cells and specifically cleaves GPI-anchored proteins. Liver has the highest level of GPI-PLD expression and is the primary organ contributing to GPLD1 in the serum. GPLD1 is abundant in serum in which it associates with polipoproteins AI and AIV. Increased serum GPLD1 is associated with insulin resistance and elevated serum triglycerides. Many surface proteins are attached to eukaryotic cell membranes via glycosylphosphatidylinositol (GPI) anchors that are covalently bound to the C-terminus of the protein and cleavage of the GPI moiety by GPLD1, only enzyme known that cleavage GPI anchor, may represent a means of regulating attachment of these proteins to the cell surface, or alternatively, their release into the extracellular environment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Glycoprotein phospholipase D; Glycosyl-phosphatidylinositol-specific phospholipase D; glycosylphosphatidylinositol phospholipase D; GPI-PLD; GPI-specific phospholipase D; MGC22590; Phosphatidylinositol-glycan-specific phospholipase D; PI-G PLD
Gene Aliases: 6330541J12Rik; AW546131; GPIPLD; GPIPLDM; GPLD1; PIGPLD; PIGPLD1; PLD
UniProt ID: (Human) P80108, (Rat) Q8R2H5
Entrez Gene ID: (Human) 2822, (Rat) 291132, (Mouse) 14756
ossification
cell migration involved in sprouting angiogenesis
chondrocyte differentiation
complement receptor mediated signaling pathway
lipid metabolic process
negative regulation of cell proliferation
insulin receptor signaling pathway
protein secretion
response to glucose
positive regulation of endothelial cell migration
positive regulation of alkaline phosphatase activity
positive regulation of triglyceride biosynthetic process
negative regulation of triglyceride catabolic process
positive regulation of glucose metabolic process
positive regulation of high-density lipoprotein particle clearance
cellular response to insulin stimulus
hematopoietic stem cell migration
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of apoptotic process
phosphatidylcholine metabolic process
positive regulation of membrane protein ectodomain proteolysis
transepithelial transport
cellular response to cholesterol
cellular response to triglyceride
cellular response to xenobiotic stimulus
cellular response to pH
hematopoietic stem cell migration to bone marrow
regulation of cellular response to insulin stimulus
GPI anchor release
cellular response to drug
positive regulation of cytolysis
positive regulation of secretion
cellular response to inorganic substance
cellular response to calcium ion
cellular response to iron(II) ion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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