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Invitrogen
GPM6A Polyclonal Antibody
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Product Details
PA5-142638
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-QTYFEMARTAGD.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Additional Information: This antibody is expected to recognize all reported isoforms (NP_005268.1; NP_963885.1; NP_963886.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
This antibody is not recommended for ICC/IF.
Target Information
Neuronal membrane glycoprotein M6-a is a protein that in humans is encoded by the GPM6A gene. Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca2+ influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: M6a; Neuronal membrane glycoprotein M6-a; unnamed protein product
Gene Aliases: GPM6; GPM6A; M6A
UniProt ID: (Human) P51674, (Mouse) P35802, (Rat) Q812E9
Entrez Gene ID: (Human) 2823, (Mouse) 234267, (Rat) 306439
neuron migration
neural retina development
nervous system development
synapse assembly
response to bacterium
neuron projection development
neuron projection morphogenesis
stem cell differentiation
regulation of synapse organization
positive regulation of filopodium assembly
calcium ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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