Product References
Multiple interactions of the dynein-2 complex with the IFT-B complex are required for effective intraflagellar transport.
Journal of cell science
Hiyamizu S,Qiu H,Vuolo L,Stevenson NL,Shak C,Heesom KJ,Hamada Y,Tsurumi Y,Chiba S,Katoh Y,Stephens DJ,Nakayama K
Wed Mar 01 00:00:00 EST 2023
Ubiquitylation of BBSome is required for ciliary assembly and signaling.
EMBO reports
Chiuso F,Delle Donne R,Giamundo G,Rinaldi L,Borzacchiello D,Moraca F,Intartaglia D,Iannucci R,Senatore E,Lignitto L,Garbi C,Conflitti P,Catalanotti B,Conte I,Feliciello A
Wed Apr 05 00:00:00 EDT 2023
Rgl-exomiR-7972, a novel plant exosomal microRNA derived from fresh Rehmanniae Radix, ameliorated lipopolysaccharide-induced acute lung injury and gut dysbiosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Qiu FS,Wang JF,Guo MY,Li XJ,Shi CY,Wu F,Zhang HH,Ying HZ,Yu CH
Fri Sep 01 00:00:00 EDT 2023
The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval from cilia.
Developmental cell
Shinde SR,Mick DU,Aoki E,Rodrigues RB,Gygi SP,Nachury MV
Mon Apr 24 00:00:00 EDT 2023
Systematic analysis of cilia characteristics and Hedgehog signaling in five immortal cell lines.
PloS one
Gómez AE,Christman AK,Van De Weghe JC,Finn M,Doherty D
Mon Jan 02 00:00:00 EST 2023
The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling.
Cell reports
Schembs L,Willems A,Hasenpusch-Theil K,Cooper JD,Whiting K,Burr K,Bøstrand SMK,Selvaraj BT,Chandran S,Theil T
Tue May 17 00:00:00 EDT 2022
KIF24 depletion induces clustering of supernumerary centrosomes in PDAC cells.
Life science alliance
Mashima Y,Nohira H,Sugihara H,Dynlacht BD,Kobayashi T,Itoh H
Tue Nov 01 00:00:00 EDT 2022
Differential Roles of Tubby Family Proteins in Ciliary Formation and Trafficking.
Molecules and cells
Hong JJ,Kim KE,Park SY,Bok J,Seo JT,Moon SJ
Tue Aug 31 00:00:00 EDT 2021
Bisdemethoxycurcumin Promotes Apoptosis and Inhibits the Epithelial-Mesenchymal Transition through the Inhibition of the G-Protein-Coupled Receptor 161/Mammalian Target of Rapamycin Signaling Pathway in Triple Negative Breast Cancer Cells.
Journal of agricultural and food chemistry
Chou CH,Wang HK,Lin YC,Tsai DH,Lu MT,Ho CT,Hseu YC,Yang HL,Way TD
Wed Dec 08 00:00:00 EST 2021
Enterotoxigenic Escherichia coli infection promotes enteric defensin expression via FOXO6-METTL3-m6A-GPR161 signalling axis.
RNA biology
Zong X,Wang H,Xiao X,Zhang Y,Hu Y,Wang F,Wang Y,Lu Z
Thu Apr 01 00:00:00 EDT 2021
Cooperation of the IFT-A complex with the IFT-B complex is required for ciliary retrograde protein trafficking and GPCR import.
Molecular biology of the cell
Kobayashi T,Ishida Y,Hirano T,Katoh Y,Nakayama K
Fri Jan 01 00:00:00 EST 2021
Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ.
Science advances
Chen C,Xu Q,Zhang Y,Davies BA,Huang Y,Katzmann DJ,Harris PC,Hu J,Ling K
Tue Jun 01 00:00:00 EDT 2021
Rabl2 GTP hydrolysis licenses BBSome-mediated export to fine-tune ciliary signaling.
The EMBO journal
Duan S,Li H,Zhang Y,Yang S,Chen Y,Qiu B,Huang C,Wang J,Li J,Zhu X,Yan X
Fri Jan 15 00:00:00 EST 2021
Rabl2 GTP hydrolysis licenses BBSome-mediated export to fine-tune ciliary signaling.
The EMBO journal
Duan S,Li H,Zhang Y,Yang S,Chen Y,Qiu B,Huang C,Wang J,Li J,Zhu X,Yan X
Fri Jan 15 00:00:00 EST 2021
Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry.
Biology open
Qiu H,Fujisawa S,Nozaki S,Katoh Y,Nakayama K
Mon Jan 25 00:00:00 EST 2021
ARL3 and ARL13B GTPases participate in distinct steps of INPP5E targeting to the ciliary membrane.
Biology open
Fujisawa S,Qiu H,Nozaki S,Chiba S,Katoh Y,Nakayama K
Wed Sep 15 00:00:00 EDT 2021
Vertebrate cells differentially interpret ciliary and extraciliary cAMP.
Cell
Truong ME,Bilekova S,Choksi SP,Li W,Bugaj LJ,Xu K,Reiter JF
Thu May 27 00:00:00 EDT 2021
FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue.
Cell reports
Zhang Y,Hao J,Tarrago MG,Warner GM,Giorgadze N,Wei Q,Huang Y,He K,Chen C,Peclat TR,White TA,Ling K,Tchkonia T,Kirkland JL,Chini EN,Hu J
Tue Aug 03 00:00:00 EDT 2021
Roles of TOG and jelly-roll domains of centrosomal protein CEP104 in its functions in cilium elongation and Hedgehog signaling.
The Journal of biological chemistry
Yamazoe T,Nagai T,Umeda S,Sugaya Y,Mizuno K
Fri Oct 23 00:00:00 EDT 2020
Primary cilium remodeling mediates a cell signaling switch in differentiating neurons.
Science advances
Toro-Tapia G,Das RM
Fri May 01 00:00:00 EDT 2020
Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia.
The Journal of cell biology
Shinde SR,Nager AR,Nachury MV
Mon Dec 07 00:00:00 EST 2020
TULP3 is required for localization of membrane-associated proteins ARL13B and INPP5E to primary cilia.
Biochemical and biophysical research communications
Han S,Miyoshi K,Shikada S,Amano G,Wang Y,Yoshimura T,Katayama T
Tue Jan 29 00:00:00 EST 2019
TULP3 is required for localization of membrane-associated proteins ARL13B and INPP5E to primary cilia.
Biochemical and biophysical research communications
Han S,Miyoshi K,Shikada S,Amano G,Wang Y,Yoshimura T,Katayama T
Tue Jan 29 00:00:00 EST 2019
Cannabinoids Exacerbate Alcohol Teratogenesis by a CB1-Hedgehog Interaction.
Scientific reports
Fish EW,Murdaugh LB,Zhang C,Boschen KE,Boa-Amponsem O,Mendoza-Romero HN,Tarpley M,Chdid L,Mukhopadhyay S,Cole GJ,Williams KP,Parnell SE
Tue Nov 05 00:00:00 EST 2019
C11ORF74 interacts with the IFT-A complex and participates in ciliary BBSome localization.
Journal of biochemistry
Takahara M,Kunii M,Nakamura K,Harada A,Hirano T,Katoh Y,Nakayama K
Fri Mar 01 00:00:00 EST 2019
RABL2 positively controls localization of GPCRs in mammalian primary cilia.
Journal of cell science
Dateyama I,Sugihara Y,Chiba S,Ota R,Nakagawa R,Kobayashi T,Itoh H
Wed Jan 16 00:00:00 EST 2019
RABL2 positively controls localization of GPCRs in mammalian primary cilia.
Journal of cell science
Dateyama I,Sugihara Y,Chiba S,Ota R,Nakagawa R,Kobayashi T,Itoh H
Wed Jan 16 00:00:00 EST 2019
Requirement of IFT-B-BBSome complex interaction in export of GPR161 from cilia.
Biology open
Nozaki S,Castro Araya RF,Katoh Y,Nakayama K
Tue Sep 17 00:00:00 EDT 2019
Robust interaction of IFT70 with IFT52-IFT88 in the IFT-B complex is required for ciliogenesis.
Biology open
Takei R,Katoh Y,Nakayama K
Mon Apr 30 00:00:00 EDT 2018
Robust interaction of IFT70 with IFT52-IFT88 in the IFT-B complex is required for ciliogenesis.
Biology open
Takei R,Katoh Y,Nakayama K
Mon Apr 30 00:00:00 EDT 2018
Interaction of WDR60 intermediate chain with TCTEX1D2 light chain of the dynein-2 complex is crucial for ciliary protein trafficking.
Molecular biology of the cell
Hamada Y,Tsurumi Y,Nozaki S,Katoh Y,Nakayama K
Sun Jul 01 00:00:00 EDT 2018
Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis.
Human molecular genetics
Takahara M,Katoh Y,Nakamura K,Hirano T,Sugawa M,Tsurumi Y,Nakayama K
Thu Feb 01 00:00:00 EST 2018
Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling.
Nature communications
Hong SR,Wang CL,Huang YS,Chang YC,Chang YC,Pusapati GV,Lin CY,Hsu N,Cheng HC,Chiang YC,Huang WE,Shaner NC,Rohatgi R,Inoue T,Lin YC
Mon Apr 30 00:00:00 EDT 2018
Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling.
Nature communications
Hong SR,Wang CL,Huang YS,Chang YC,Chang YC,Pusapati GV,Lin CY,Hsu N,Cheng HC,Chiang YC,Huang WE,Shaner NC,Rohatgi R,Inoue T,Lin YC
Mon Apr 30 00:00:00 EDT 2018
A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.
Oncogene
Conduit SE,Ramaswamy V,Remke M,Watkins DN,Wainwright BJ,Taylor MD,Mitchell CA,Dyson JM
Thu Oct 26 00:00:00 EDT 2017
A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.
Oncogene
Conduit SE,Ramaswamy V,Remke M,Watkins DN,Wainwright BJ,Taylor MD,Mitchell CA,Dyson JM
Thu Oct 26 00:00:00 EDT 2017
INPP5E regulates phosphoinositide-dependent cilia transition zone function.
The Journal of cell biology
Dyson JM,Conduit SE,Feeney SJ,Hakim S,DiTommaso T,Fulcher AJ,Sriratana A,Ramm G,Horan KA,Gurung R,Wicking C,Smyth I,Mitchell CA
Mon Jan 02 00:00:00 EST 2017
INPP5E regulates phosphoinositide-dependent cilia transition zone function.
The Journal of cell biology
Dyson JM,Conduit SE,Feeney SJ,Hakim S,DiTommaso T,Fulcher AJ,Sriratana A,Ramm G,Horan KA,Gurung R,Wicking C,Smyth I,Mitchell CA
Mon Jan 02 00:00:00 EST 2017
Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E.
Journal of cell science
Nozaki S,Katoh Y,Terada M,Michisaka S,Funabashi T,Takahashi S,Kontani K,Nakayama K
Wed Feb 01 00:00:00 EST 2017
Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E.
Journal of cell science
Nozaki S,Katoh Y,Terada M,Michisaka S,Funabashi T,Takahashi S,Kontani K,Nakayama K
Wed Feb 01 00:00:00 EST 2017
The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling.
PloS one
Goetz SC,Bangs F,Barrington CL,Katsanis N,Anderson KV
Fri Sep 08 00:00:00 EDT 2017
The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling.
PloS one
Goetz SC,Bangs F,Barrington CL,Katsanis N,Anderson KV
Fri Sep 08 00:00:00 EDT 2017
Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling.
Developmental cell
Garcia-Gonzalo FR,Phua SC,Roberson EC,Garcia G,Abedin M,Schurmans S,Inoue T,Reiter JF
Mon Aug 24 00:00:00 EDT 2015
Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling.
Developmental cell
Garcia-Gonzalo FR,Phua SC,Roberson EC,Garcia G,Abedin M,Schurmans S,Inoue T,Reiter JF
Mon Aug 24 00:00:00 EDT 2015
Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling.
PLoS genetics
Yee LE,Garcia-Gonzalo FR,Bowie RV,Li C,Kennedy JK,Ashrafi K,Blacque OE,Leroux MR,Reiter JF
Sun Nov 01 00:00:00 EDT 2015
Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling.
PLoS genetics
Yee LE,Garcia-Gonzalo FR,Bowie RV,Li C,Kennedy JK,Ashrafi K,Blacque OE,Leroux MR,Reiter JF
Sun Nov 01 00:00:00 EDT 2015