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GPVI Polyclonal Antibody
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FIGURE: 1 / 4
GPVI Antibody (600-401-BN1) in ICC/IF
Immunofluorescence Microscopy of GPVI antibody. Tissue: Human heart cells. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: GPVI antibody at 20 µg/mL for 1 hr at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Staining: GPVI as a red fluorescent signal.
Product Details
600-401-BN1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-GPVI antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide near the C-terminus of the human GPVI.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Glycoprotein 5; Glycoprotein 6; glycoprotein 6 (platelet); GPVI; platelet collagen receptor; Platelet glycoprotein VI
Gene Aliases: 9830166G18Rik; BDPLT11; Gm469; GP6; GPIV; GPVI
UniProt ID: (Human) Q9HCN6, (Mouse) P0C191
Entrez Gene ID: (Human) 51206, (Mouse) 243816, (Rat) 684555
immune response-regulating signaling pathway
enzyme linked receptor protein signaling pathway
blood coagulation
hemostasis
platelet activation
collagen-activated tyrosine kinase receptor signaling pathway
collagen-activated signaling pathway
platelet aggregation
positive regulation of platelet aggregation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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