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In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on human chromosome 15q13--> q15. DRM-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis.
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Protein Aliases: Cysteine knot superfamily 1, BMP antagonist 1; Down-regulated in Mos-transformed cells protein; down-regulated in v-mos-transformed cells; Gremlin-1
Gene Aliases: Cktsf1b1; Drm; Grem; Grem1; ld
UniProt ID: (Mouse) O70326
Entrez Gene ID: (Mouse) 23892