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Proteintech
GRIA4 Polyclonal Antibody
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Product Details
23350-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GRIA4 Fusion Protein Ag19949 (87-229 aa encoded by BC167786)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: YSRGVFAIF GLYDKRSVHT LTSFCSALHI SLITPSFPTE GESQFVLQLR PSLRGALLSL LDHYEWNCFV FLYDTDRGYS ILQAIMEKAG QNGWHVSAIC VENFNDVSYR QLLEELDRRQ EKKFVIDCEI ERLQNILEQI VSVG (87-229 aa encoded by BC167786)
Target Information
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate, whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AMPA-selective glutamate receptor 4; GluA4; GluR-4; GluR-D; glutamate receptor; Glutamate receptor 4; glutamate receptor channel alpha 4; Glutamate receptor ionotropic, AMPA 4; glutamate receptor, ionotrophic, AMPA 4; glutamate receptor, ionotropic, AMPA 4; glutamate receptor, ionotropic, AMPA4 (alpha 4); spike wave 1
Gene Aliases: GluA4; GluA4-ATD; Glur-4; GluR-D; GLUR4; GLUR4C; Gluralpha4; GLURD; GRIA4; NEDSGA; spkw1
UniProt ID: (Human) P48058, (Mouse) Q9Z2W8, (Rat) P19493
Entrez Gene ID: (Human) 2893, (Mouse) 14802, (Rat) 29629
beta-amyloid binding
ionotropic glutamate receptor activity
AMPA glutamate receptor activity
ion channel activity
protein binding
ligand-gated ion channel activity
signaling receptor activity
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
receptor activity
extracellular-glutamate-gated ion channel activity
transmembrane signal receptor
ion transport
glutamate receptor signaling pathway
ion transmembrane transport
negative regulation of smooth muscle cell apoptotic process
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
modulation of synaptic transmission
regulation of postsynaptic membrane potential
regulation of presynaptic membrane potential
transport
chemical synaptic transmission
positive regulation of synaptic transmission, glutamatergic
regulation of synapse structure or activity
response to fungicide
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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