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Proteintech
GRIK5 Polyclonal Antibody
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Product Details
28550-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GRIK5 fusion protein Ag29363
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MLQELRHAVS CRKTSRSRRR RRPGGPSRAL LSLRAVREMR LSNGKLYSAG AGGDAGSAGG PQRLLDDPGP PSGARPAAPT PCTHVRVCQE CRRIQALRAS GAGAPPRGLG VPAEATSPPR PRPGPAGPRE LAEHE
Target Information
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik5, also known as kainate-preferring glutamate recptor subunit KA2, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik5 is highly homologous to the related ionotrophic glutamate receptor Grik4 (also known as KA1). Like Grik4, Grik5 does not form homomeric channels, but instead forms heteromers with Grik2. In Grik2- but not Grik1-null mice, Grik5 surface expression is greatly reduced in neurons, indicating that Grik2/Grik5 heteromers are required for exit from the endoplasmic reticulum to the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EAA2; Excitatory amino acid receptor 2; GluK5; GluR gamma-2; glutamate receptor; Glutamate receptor gamma-2; Glutamate receptor ionotropic, kainate 5; Glutamate receptor KA-2; glutamate receptor KA2; glutamate receptor, ionotropic kainate 5; glutamate receptor, ionotropic, kainate 5; KA2
Gene Aliases: EAA2; GluK5; GluRgamma2; GRIK2; GRIK5; iGlu5; KA2
UniProt ID: (Human) Q16478, (Rat) Q63273, (Mouse) Q61626
Entrez Gene ID: (Human) 2901, (Rat) 24407, (Mouse) 14809
extracellular-glutamate-gated ion channel activity
ligand-gated ion channel activity
kainate selective glutamate receptor activity
SH3 domain binding
PDZ domain binding
identical protein binding
protein binding
glutamate receptor activity
receptor activity
ionotropic glutamate receptor activity
ion channel activity
transmembrane signal receptor
protein retention in ER lumen
regulation of synaptic vesicle fusion to presynaptic membrane
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
receptor clustering
positive regulation of neuron apoptotic process
establishment of localization in cell
excitatory postsynaptic potential
cellular response to glucose stimulus
signal transduction
chemical synaptic transmission
regulation of membrane potential
transport
ion transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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