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The sensation of sight is the result of a cascade of events starting with the interaction of photoactivated rhodopsin with a protein called transducin. Rhodopsin kinase is a G-protein-coupled Ser/Thr kinase, also known as GRK1, which is a key element in the regulation of this cascade. Following phosphorylation by GRK1, arrestin is recruited to phospho-rhodopsin quenching its phototransductive activity by preventing further interaction with transducin. By breaking the cycle of phototransduction, GRK1 plays an important role in the restoration of the system for subsequent visual events.
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Protein Aliases: G protein-coupled receptor kinase 1; G-protein receptor kinase 1; Rhodopsin kinase; Rhodopsin kinase GRK1; RK
Gene Aliases: GPRK1; GRK1; RHOK; RK
UniProt ID: (Human) Q15835
Entrez Gene ID: (Human) 6011, (Mouse) 24013
Molecular Function:
kinase
non-receptor serine/threonine protein kinase
protein kinase
transferase
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