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|Tested species reactivity||Human, Mouse, Primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 633-660 amino acids from the C-terminal region of human AD_K2|
|Purification||Size-exclusion - Dialysis, Ammonium sulfate precipitation|
|Contains||0.09% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the ADRBK2 enzyme, also known as GRK3, has 85% amino acid similarity with ADRBK1, with the protein kinase catalytic domain having 95% similarity. The ADRBK2 mRNA is approximately 8 kilobases with a distribution similar to that of ADRBK1. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
adrenergic, beta, receptor kinase 2; beta ARK2; beta-adrenergic receptor kinase 2; beta-ARK-2; G-protein coupled receptor kinase 3; G-protein-coupled receptor kinase 3
4833444A01Rik; Adrbk-2; ADRBK2; AI851927; AW551196; Bark-2; BARK2; GRK3