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NeoBiotechnologies
GRP94/HSP90B1 (Endoplasmic Reticulum Marker) Monoclonal Antibody (SPM249)
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Product Details
7184-RTM1X-P0
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Chicken,
Horse,
Guinea pig,
Hamster,
Human,
Mouse,
Non-human primate,
Sheep,
Pig,
Rabbit,
Rat,
Xenopus
Host/Isotype
Rat
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
SPM249
Immunogen
Purified glucose regulated protein 94 (grp94) from chicken oviducts
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
20 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
GRP94 is a 803 amino acid protein belonging to the heat shock protein 90 family. It acts as a molecular chaperone that functions in the processing and transport of secreted proteins. GRP94 and its N-terminal fragment stimulates CTL expansion and maturation of human monocyte-derived dendritic cells (MDDC). It plays a central role in innate as well as acquired immunity, maturation and chemotaxis of dendritic cells, Ab production, cross-priming, as a potential marker in breast cancer and is a peptide acceptor in endoplasmic reticulum and an accessory to peptide loading of MHC class I molecules. Expression of GRP94 suppressed A23187-induced apoptosis and stabilized calcium homeostasis. GRP94 is expressed in melanoma or liver metastases of colon carcinoma cells, human gastric carcinoma BGC-823 cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 108K heat shock protein; 108K HSP; 94 kDa glucose-regulated protein; 94 kDa glucose-regulated protein {ECO:0000250|UniProtKB:P08113}; 98 kDa protein kinase; Endoplasmic reticulum resident protein 99; Endoplasmin; endoplasmin {ECO:0000250|UniProtKB:P08113}; endoplasmin-like protein; endothelial cell (HBMEC) glycoprotein; epididymis luminal protein 35; epididymis secretory sperm binding protein Li 125m; ERp99; glucose-regulated protein; glucose-regulated protein GRP94; gp96 homolog; GRP-94; GRP94; Heat shock 108 kDa protein; heat shock protein 108; heat shock protein 108.; Heat shock protein 90 kDa beta member 1; heat shock protein 90 kDa beta member 1 {ECO:0000250|UniProtKB:P08113}; heat shock protein 90, beta (Grp94), member 1; heat shock protein 90kDa beta (Grp94), member 1; heat shock protein 90kDa beta family member 1; heat shock protein 90kDa beta, member 1; Heat shock protein family C member 4; heat shock protein gp96; HSP 108; hsp108; HSP90 beta; hsp90b1 {ECO:0000250|UniProtKB:P08113}; Polymorphic tumor rejection antigen 1; PPK 98; stress-inducible tumor rejection antigen gp96; Transferrin-binding protein; transforming growth factor alpha regulated gene 2; tumor rejection antigen; tumor rejection antigen (gp96) 1; Tumor rejection antigen 1; Tumor rejection antigen gp96; unnamed protein product
Gene Aliases: ECGP; endoplasmin; ERp99; GP96; GRP94; HEL-S-125m; HEL35; hsp108; HSP90B1; HSPC4; ppk98; TA-3; Targ2; Tra-1; TRA1; XELAEV_18017384mg
RNA binding
ATP binding
protein phosphatase binding
low-density lipoprotein particle receptor binding
unfolded protein binding
nucleotide binding
protein phosphatase inhibitor activity
calcium ion binding
protein binding
hydrolase activity
ATPase activity
protein binding involved in protein folding
ATP-dependent protein folding chaperone
virion binding
Hsp90 family chaperone
response to hypoxia
ER-associated ubiquitin-dependent protein catabolic process
retrograde protein transport, ER to cytosol
actin rod assembly
negative regulation of apoptotic process
regulation of phosphoprotein phosphatase activity
cellular response to ATP
protein folding
intracellular sequestering of iron ion
protein transport
positive regulation of Wnt signaling pathway
positive regulation of toll-like receptor signaling pathway
protein folding in endoplasmic reticulum
response to endoplasmic reticulum stress
ERAD pathway
sequestering of calcium ion
cellular response to manganese ion
protein localization to plasma membrane
response to stress
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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