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GTPase HRAS Polyclonal Antibody

View all (29) H-Ras antibodies

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GTPase HRAS Polyclonal Antibody

Product Details

P21RAS-121AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Chicken, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 139-189 on human GTPase HRAS protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Monomeric G protein Ras functions as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to a number of downstream signaling pathways leading to distinct cytoplasmic or nuclear events. Each mammalian cell contains three Ras proto-oncogene coding for closely related Ras proteins: H-, K-, N-Ras. Oncogenic mutations in Ras genes are present in ~30% of all human cancers. Constitutive activation of Ras due to mutations or overexpression stimulates proliferation and inhibition of apoptosis. K-Ras mutations are common in pancreatic, colorectal and nonsmall-cell lung carcinomas; H-Ras mutations are common in bladder, kidney and thyroid carcinomas; N-Ras mutations are found in melanoma, hematological malignancies and hepatocellular carcinaoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-H-ras; c-Ha-ras p21 protein; c-Ha-ras transgene; c-has/bas p21 protein; GTP- and GDP-binding peptide B; GTPase Hras1; H-ras 1 protein; H-Ras-1; Ha-Ras1 proto-oncoprotein; Harvey ras1 protein; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; Harvey rat sarcoma viral oncogene homolog; Harvey rat sarcoma viral oncoprotein; Harvey rat sarcoma virus oncogene; Harvey rat sarcoma virus oncogene 1; HRAS; p19 H-RasIDX protein; p21ras; Ras family small GTP binding protein H-Ras; small GTP binding protein; transformation gene: oncogene HAMSV; transforming protein P21; unnamed protein product; v-Ha-ras Harvey rat sarcoma viral oncogene homolog; v-Ha-ras Harvey rat sarcoma viral oncogene-like protein

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Gene Aliases: C-BAS/HAS; C-H-RAS; c-Ha-ras; C-HA-RAS1; c-rasHa; CTLO; H-RAS; H-RASIDX; Ha-ras; HAMSV; Harvey-ras; Hras-1; HRAS1; Kras2; p21ras; ras; RASH1

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UniProt ID: (Human) P01112, (Chicken) P08642, (Mouse) Q61411, (Rat) P20171

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Entrez Gene ID: (Human) 3265, (Chicken) 396229, (Mouse) 15461, (Rat) 293621

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Function(s)
GTPase activity obsolete small monomeric GTPase activity protein binding GTP binding GDP binding protein anchor phospholipase C activator activity protein C-terminus binding macromolecular complex binding small GTPase
Process(es)
MAPK cascade regulation of transcription from RNA polymerase II promoter chemotaxis signal transduction cell surface receptor signaling pathway Ras protein signal transduction positive regulation of cell proliferation negative regulation of cell proliferation insulin receptor signaling pathway organ morphogenesis negative regulation of gene expression Schwann cell development positive regulation of cell migration regulation of actin cytoskeleton organization regulation of cell proliferation myelination positive regulation of MAPK cascade positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of Ras protein signal transduction positive regulation of epithelial cell proliferation regulation of cell cycle adipose tissue development positive regulation of ERK1 and ERK2 cascade cellular response to gamma radiation positive regulation of wound healing positive regulation of protein targeting to membrane cellular senescence regulation of neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of ruffle assembly positive regulation of miRNA metabolic process endocytosis cell cycle arrest mitotic cell cycle checkpoint positive regulation of phospholipase C activity positive regulation of interferon-gamma production negative regulation of GTPase activity T-helper 1 type immune response defense response to protozoan positive regulation of MAP kinase activity negative regulation of neuron apoptotic process positive regulation of GTPase activity regulation of long-term neuronal synaptic plasticity T cell receptor signaling pathway intrinsic apoptotic signaling pathway positive regulation of actin cytoskeleton reorganization small GTPase mediated signal transduction positive regulation of gene expression ERBB2-ERBB3 signaling pathway insulin-like growth factor receptor signaling pathway oncogene-induced cell senescence liver development response to isolation stress positive regulation of DNA replication
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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