This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PA5-29910 targets Gelsolin in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-29910 immunogen is recombinant fragment corresponding to a region within amino acids 111 and 399 of Human Gelsolin.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
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Protein Aliases: Actin-depolymerizing factor; ADF; AGEL; Brevin; Gelsolin
Gene Aliases: ADF; AGEL; GSN
UniProt ID: (Human) P06396
Entrez Gene ID: (Human) 2934